S. Zhang

The paper shows that susceptible Pi-ta alleles are retained due to their fitness benefit by acting as an off-switch for immune signaling.

The paper investigates whether F1 hybrids between Drosophila species are less attractive than pure species and finds that pure species strongly discriminate against hybrids.

This study integrates proteomic data from human and mouse macrophages to analyze posttranslational modifications in the inflammatory response, identifying PTM crosstalk and novel inflammatory proteins.

This study uses CITE-seq to analyze brain immune cell plasticity in aged mice with and without gut dysbiosis, revealing transcriptional shifts in monocytes and ILCs linked to neuroinflammation.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper identifies a small molecule that specifically binds to a tandem UU:GA mismatch motif in RNA, highlighting the importance of motif context for small molecule targeting.

This study identifies an OsNCED2 allele that enhances aerobic adaptation in upland rice by improving root development and drought tolerance through increased ABA synthesis.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This study shows that blood collection tubes affect biomarker screening results in mass spectrometry, with coagulant tubes altering protein profiles and reducing biomarker detection.

This study investigates glycyrrhizin's effect on LPS-induced inflammation in goat ruminal epithelial cells, finding it reduces inflammatory cytokines and protects cell structure.

This paper introduces a joint Bayesian model to analyze lab validation and field survey data together, showing it improves prevalence and test characteristic estimates compared to separate analyses.

The paper identifies a SARS-CoV-2 spike protein motif with superantigen-like properties that may contribute to MIS-C and cytokine storms in COVID-19 patients.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

This study identifies PSGL-1 as an HIV restriction factor that inhibits HIV DNA synthesis and virion infectivity by restricting actin dynamics and sequestering HIV envelope proteins.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

This study shows that blocking CTLA-4 reverses Treg cell suppression of anti-TB T-cell responses in tuberculosis patients.

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

This study shows that Asgard archaea possess ESCRT complexes with eukaryotic-like structural and functional features, suggesting they are evolutionary precursors to eukaryotic ESCRTs.

This study shows mitochondrial and cytosolic reactive oxygen species are not required for HIF1α stability under hypoxia, suggesting HIF prolyl hydroxylase inhibition could be therapeutically beneficial.

The paper introduces 2D-HELS-AA MS Seq to directly sequence tRNA, revealing different isoforms and dynamic base modifications.

This study identifies Rab18's role in lipid droplet dynamics by showing it binds PLIN2 and ACSL3, promoting TAG accumulation and LD growth in muscle cells.

This study presents the genome of Penium margaritaceum, a charophyte alga, to explore evolutionary features leading to land plant colonization and identifies gene expansions and adaptations related to terrestrialization.

The paper studies the binding and enzymatic activity of LD proteins using adiposomes, showing PI's effect on PLIN2 and ATGL.

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

The paper identifies noncoding RNA-encoded proteins on lipid droplets, discovering LDANP1 which modulates lipid metabolism and insulin sensitivity.

The paper investigates how lipid droplet-anchored mitochondria in brown adipocytes respond to cold temperatures and identifies differences in protein expression between these mitochondria and cytoplasmic mitochondria.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

This paper develops a genetically defined, syngeneic organoid platform for ovarian cancer to evaluate combination therapies and finds genotype-specific responses to immunotherapy and chemotherapy.