S. Zhu

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

This study shows that Tmem138 is essential for rhodopsin transport across the photoreceptor connecting cilium and outer segment biogenesis, with its absence causing photoreceptor degeneration.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

This paper develops sex-specific TdP risk classifiers using cardiac simulations and machine learning, finding that male-based models underestimate female TdP risk.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

The paper identifies novel root growth regulators in Arabidopsis root tips through analysis of auxin-triggered (phospho)proteome changes.

The paper develops a method to trace the geographic origin of quarantine insects using their gut microbiota, finding that microbiota diversity and composition correlate with geographic and environmental factors.

This study shows that Sirt5 deficiency increases protein malonylation and disrupts metabolism in chondrocytes under obesity conditions, linking it to osteoarthritis progression.

This study investigates TRPM2's role in pancreatic cancer, finding it promotes proliferation, migration, and invasion through the PKC/MAPK pathway.

This paper shows that mitochondrial stress from mtROS and mtRES triggers mitohormesis in macrophages, leading to tolerance by suppressing proinflammatory gene transcription.

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

This study identifies two monoclonal antibodies that bind SARS-CoV-2 spike protein RBM and inhibit GM-CSF induction in immune cells.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

This paper introduces AquaDust, a hydrogel nanoreporter for in situ measurement of leaf water potential in plants, demonstrating its ability to detect water potential gradients and support hydraulic modeling.

This paper develops a particle filter for continuous Markov jump processes to infer population demographics from genetic data, showing improved accuracy in estimating past population sizes.

This study uses cryo-electron tomography to show that the C-ring of Vibrio alginolyticus undergoes structural remodeling during rotational switching.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This paper introduces a method to sort single cells based on secreted products using microparticles, enabling high-throughput screening of cell function.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study investigates how peptidoglycan-deficient spherical spores of Myxococcus xanthus germinate into rod-shaped cells by elucidating the role of MglB, MglA, MreB, and molecular motors in de novo PG synthesis and shape establishment.

This study identifies and characterizes two bacterial enzymes, DgpA and DgpB-C complex, that work together with 3-oxo-glucose to degrade the C-glucoside puerarin through a β-elimination mechanism.

This study uses full-length transcriptome sequencing to analyze salt tolerance mechanisms in Spartina alterniflora and identifies key genes and regulatory networks involved in stress response.

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

This study evaluates the in vitro and in vivo synergistic effects of linezolid and fosfomycin against vancomycin-susceptible and -resistant enterococci using a Galleria mellonella model.

This study identifies the H-ring as a novel structure facilitating outer membrane penetration and flagellar assembly in Vibrio alginolyticus using cryo-electron tomography.

The paper analyzes early proteome and phosphoproteome changes in Arabidopsis under mild mannitol stress and identifies AHA2 and CRRSP38 as novel regulators of shoot growth under osmotic stress.

The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.