T. Nguyen

This study identifies cluster-specific gene markers for Shigella and EIEC strains and develops a tool, ShigEiFinder, to accurately differentiate and serotype them with high accuracy.

This study shows that Bcl-xL at the endoplasmic reticulum (ER) dampens the unfolded protein response (UPR) by reducing IP3R-mediated calcium release, thereby preventing ER calcium depletion and cell death.

This study identifies betulonic acid derivatives as inhibitors of coronavirus replication by targeting the nsp15 endoribonuclease, with EC50 of 0.6 M against 229E.

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

This study shows that truncating the CD8 hinge domain in CARs can finely tune antigen sensitivity, improving selectivity for tumor cells over healthy ones.

This study shows that Smad3 in smooth muscle cells prevents harmful plaque changes in atherosclerosis by blocking specific cell transitions that lead to calcification and inflammation.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

The paper identifies hPDGFRβ as a host receptor for the malaria parasite TRAP, showing its role in sporozoite motility and infection.

This paper introduces SCIPs, CRISPR plasmids that integrate themselves at targeted genomic sites, enabling efficient and programmable gene editing in mammalian cells.

This study defines the chemokine profiles of pathogen-specific effector T cells and identifies their temporospatial organization and regulatory mechanisms.

The paper shows that SIDT2 promotes tumor development in lung and gastrointestinal cancers by facilitating RNautophagy, as evidenced by reduced tumor formation in Sidt2-/- mice with oncogenic KrasG12D or Apcmin/+ mutations.

This study shows FGFR1 stabilizes N-cadherin at cell-cell contacts, enhancing adhesion and reducing cell migration through Src and p120 pathways.

This paper develops an LCMS-based assay to detect DOACs in trauma patients, achieving high accuracy and identifying potential medication reconciliation issues.

The paper identifies 200 factors involved in human ER-phagy through CRISPRi screening and reveals mitochondrial metabolism and ER-resident UFMylation as key regulators.

This study shows CEACAM1 regulates IL-6 production in murine monocytes via RP105, affecting the fever response to LPS.

This study develops an ex vivo dengue virus neutralization assay using mosquitoes to identify potent human monoclonal antibodies and their epitopes for vaccine and therapeutic development.

The paper identifies cross-cancer metastasis biomarkers by analyzing miRNA-mRNA expression in paired tumor samples across 11 cancer types.

This study shows that inhibiting thrombocyte activation improves control of mycobacterial infection by reducing thrombocyte-macrophage interactions and restoring macrophage immunity.

This study shows that aging enhances CD8+ memory T cell recall responses by utilizing diverse molecular mechanisms, supporting the rebound model of immune memory.

This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.

This study shows that aging of antiviral CD8+ memory T cells leads to increased survival, metabolic adaptations, and lymphoid tissue homing, enhancing their recall response capabilities.

This study sequences HHV-6B and iciHHV-6 genomes, identifies geographic clustering and recombination in active infections, and reannotates the HHV-6B genome using transcriptomics and proteomics.

The paper analyzes gene expression evolution after whole-genome duplication in teleost fish using the spotted gar genome and PhyloFish data, showing rapid fate determination of duplicates and ongoing functional divergence.

The paper introduces CRATER, a CRISPR/Cas9-based method that improves plasmid transformation efficiency by selectively cleaving unwanted byproducts, increasing efficiency from 20% to 97%.