T. R. O'Meara

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans

The paper uses imaging-based screening to identify compounds that inhibit hyphal transition in C. albicans, identifying eIF3 as a target of NSC 697923.

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

This paper describes a high-throughput screening method using human PBMCs to identify adjuvant candidates, resulting in a lead compound with in vivo adjuvanticity.

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

Forward and Reverse Genetic Dissection of Morphogenesis Identifies Filament-Competent Candida auris Strains

This paper identifies genes regulating morphogenesis in Candida auris using forward and reverse genetic approaches and develops tools for efficient genetic manipulation.

DeORFanizing Candida albicans Genes using Co-Expression

This paper builds a co-expression network for Candida albicans using RNA-seq data to predict gene function and identifies CCJ1 as a novel cell cycle regulator.

Selective protein O-GlcNAcylation in cells by a proximity-directed O-GlcNAc transferase

This paper introduces a method to selectively induce O-GlcNAcylation on target proteins using nanobody-fused OGT, enabling precise study of O-GlcNAc modifications in cells.