W. Sun

This paper develops a Cas9-RNAi RNP tool that combines RNAi and CRISPR for simultaneous gene knock out and knock down, and enhances homology-directed repair.

This study shows JQ-1 reduces liver granuloma size and egg production in Schistosoma japonicum-infected mice by inhibiting reproductive system development and gene expression.

The paper examines fecal IgA abundance and nuclear antigen reactivity in lupus-prone mouse models, finding gender and model-specific variations that correlate with future autoantibody levels.

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

This study evaluates off-target mutations caused by high-activity adenine base editors in rice, finding that TadA9 variants and CRISPR/SpCas9n-NG increase off-target A>G SNVs, with RNA mutations clustering more than DNA mutations.

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

This study investigates how Pkc53E regulates adducin to remodel the actin cytoskeleton in Drosophila photoreceptors, showing that Pkc53E phosphorylates adducin and that its loss exacerbates retinal degeneration.

This study shows that a gnotobiotic microbiota affects metabolic processes differently depending on the circadian cycle, influencing energy balance and substrate utilization.

This study identifies specific HA mutations in H9N2 avian influenza virus that influence antigenic variation and immune escape from vaccine antibodies.

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

The paper identifies a non-canonical transcriptional mechanism in T-ALL where GFI1 and IKAROS cooperate to transactivate NOTCH3, independent of LSD1 binding.

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

This study investigates how cardiolipin and phosphatidylglycerol lipids induce structural and dynamic changes in cytochrome c, affecting its peroxidase activity during mitochondrial apoptosis.

This study uses deep learning to predict cell sizes from laser mode imaging of single-cell lasers, demonstrating sub-wavelength accuracy in both synthetic and biological cell models.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

This paper develops an adaptive optics module for multiphoton imaging in vivo, enabling high-resolution visualization of neural structures and calcium responses in deep brain and spinal cord regions of mice.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

This paper introduces a probabilistic and anisotropic failure metric to improve risk stratification for ascending thoracic aortic aneurysm by incorporating patient-specific biomechanical data and uncertainty in wall strength.

This paper develops a regional difference-based evaluation method for ecosystem service value (ESV) in Gansu Province, China, showing increased ESV from 2000 to 2015 with forest and urban ecosystems contributing most.

This study shows SpRY expands CRISPR editing in rice by recognizing diverse PAMs, enabling efficient genome modification across various loci.

This study identifies gene mutations in SARS-CoV-2 that enhance its adaptation to humans by analyzing host-genome similarity across 2594 genomes from three continents.

This paper evaluates an inactivated Newcastle disease virus expressing the SARS-CoV-2 spike protein as a cost-effective vaccine, showing immunogenicity and protective efficacy in animal models.

This paper describes NDV vector vaccines expressing SARS-CoV-2 spike protein that protect mice from viral challenge and can be produced cost-effectively in chicken eggs.

This paper improves HDR efficiency for gene knock-in in poplar by combining XRCC4 silencing with CtIP and MRE11 overexpression, achieving higher knock-in rates and fewer InDels.

This study investigates the effect of hydrogen inhalation on SIgA, PIgR, and cytokines in a COPD rat model, finding improved expression of SIgA and related factors with higher hydrogen concentrations.

The paper examines IgA abundance and nuclear antigen reactivity in intestinal and fecal samples of lupus-prone mice, finding correlations with systemic autoimmunity onset.