W. Zhang

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study investigates stochastic motion of biomolecules in SMLM and shows that restricting this motion improves localization precision.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.

This study identifies 348 autoantigens from human A549 lung cells, revealing viral and host factors involved in autoimmunity during SARS-CoV-2 infection.

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

The paper develops a D-2-hydroxyglutarate biosensor using DhdR, which detects D-2-HG in biological samples with high specificity and sensitivity.

This study shows that age-related insulin resistance in mice is caused by both reduced CPT1B and lipid overload, not just mitochondrial dysfunction or diet alone.

The paper shows that RNA polymerase II clusters form in line with liquid phase wetting of chromatin in zebrafish embryos, using microscopy and a computational model.

This study identifies exosomal miR-130a-3p from acinar cells as a regulator of pancreatic fibrosis by targeting PPAR-γ in stellate cells, showing its role in collagen formation and fibrosis progression.

The study identifies an autoantigenome from human lung HFL1 cells using dermatan sulfate affinity, linking it to neurological and autoimmune complications of COVID-19.

This study shows that Matriptase promotes tissue damage responses by activating Gq signaling, leading to RSK and DUOX activation, which disrupts epithelial junctions and contributes to inflammation and carcinoma.

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

The paper identifies proinflammatory gut microbiome features in SLE patients through metagenomic analysis and shows potential autoimmunogenic mechanisms.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

The paper identifies a deep-sea bacterial threonine dehydratase that catalyzes cysteine desulfuration to produce hydrogen sulfide, revealing structural and functional mechanisms.

This study identifies two major phylogroups of HAdV-E4 with distinct replicative fitness and virulence phenotypes, showing no correlation between in vitro fitness and in vivo virulence.

This study identifies electrogram morphology recurrence as a marker of arrhythmogenic substrate in atrial fibrillation, suggesting it could guide targeted ablation therapy.

This study compares three porcine corneal decellularization methods and shows that preserving the limbus reduces decellularization efficiency but lessens structural damage.

This paper evaluates strategies to control cucumber green mottle mosaic virus in greenhouses using disinfectants and resistant cucumber varieties, finding that specific cleaning methods and certain varieties reduce infection spread.

This study identifies a conserved ubiquitin- and ESCRT-dependent pathway for degrading lysosomal membrane proteins in human and yeast cells.

This study investigates the effects of threo-nucleotides on nonenzymatic template-directed polymerization, finding that they are less efficient than ribo-nucleotides in primer extension.

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

This study shows NMNH enhances NAD+ and inhibits glycolysis, TCA cycle, and cell growth, but does not affect mice.

This paper describes a laboratory module using C. elegans to teach RNA interference and codon optimization through fluorescence microscopy and quantitative image analysis.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

The paper develops a dynamic binning method for improved peak detection in lipidomics LC-MS data and compares pre-processing tools for differential compound detection.

This paper introduces a hierarchical point process model for spatial capture-recapture data using non-invasive genetic sampling, estimating wolverine density without data augmentation.