X. Chen

The paper uses snRNA-seq to analyze transcriptional diversity in multinucleated skeletal myofibers, revealing distinct myonuclear populations and novel gene markers.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

This study shows that maternal vitamin D deficiency increases obesity risk in male offspring by altering immune responses and adipose tissue inflammation.

This study shows BET inhibition in breast cancer triggers an anti-apoptotic response via MCL1 upregulation, and co-targeting BET and MCL1 is synergistic and effective in basal-like breast cancers.

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

Click-ExM expands super-resolution imaging to all biomolecules by integrating click-labeling into expansion microscopy.

This study evaluates cause-specific survival in elderly differentiated thyroid cancer patients comparing surgical treatment vs. non-surgical management and the impact of RAI-131 therapy.

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

The paper identifies CAG promoter activity as a marker for reprogramming-efficient cells and shows its association with MKL1/SRF activity and cell cycle dynamics.

This paper introduces sapphire-supported nanopore membranes with reduced capacitance and noise, improving DNA sensing accuracy and speed compared to silicon-supported nanopores.

This paper identifies a novel bat coronavirus, RmYN02, with sequence similarities to HCoV-19 and natural insertions at the S1/S2 cleavage site, suggesting a possible recombinant origin for HCoV-19.

The paper identifies four metabolites that reduce Staphylococcus aureus bloodstream infection by inhibiting arginase and enhancing phagocytic killing through a nitric oxide-dependent mechanism.

This study uses atomic force microscopy to characterize the mechanical heterogeneity of different regions in murine bones, revealing significant variations in elastic and viscoelastic properties across age and tissue types.

This study compares the effects of different fertilization patterns on soil microbial diversity, structure, and function in greenhouse vegetable production systems, finding that higher manure substitution improves soil quality and microbial activity.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This paper develops a nano-sieve device for separating microalgae from bacteria and tracking single cells via auto-fluorescence.

The paper profiles miRNAs and uses degradome sequencing to study their role in CMS regulation during anther development in pepper, identifying differentially expressed miRNAs and their target transcripts.

This paper identifies an Anr-regulated hemerythrin, Mhr, that enhances fitness of Pseudomonas aeruginosa lasR mutants in microoxic conditions by binding oxygen.

This study shows hesperetin reduces foam cell formation in macrophages by activating LXRα through AMPK-dependent mechanisms, enhancing cholesterol efflux and reducing cholesterol accumulation.

This paper describes an automated peptide mapping protocol using a robotic liquid handling system to improve reproducibility and reduce hands-on time compared to manual methods.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

This study identifies adaptive divergence followed by population admixture as a source of additive genetic variance in evolutionarily important traits, showing a strong positive correlation between heritability and evolutionary importance.

The paper compares cell autonomous and systemic Akt1/Akt2 deletion effects in breast cancer, finding distinct roles in tumorigenesis and metastasis.

This study develops a chemo-mechanical model to predict how adhesions and microenvironmental properties regulate 3D cell shapes, validated with experiments on HT1080 cells and literature data.

The paper identifies compensatory metabolic mechanisms in tumours and shows that targeting these can improve therapeutic outcomes.

This study improves subspecies identification of Mycobacterium abscessus complex using whole genome sequencing by developing a method based on rpoB, erm(41), and rpls genes, achieving 100% accuracy in public and clinical isolates.

The paper introduces DDC, a method to correct blinking artifacts in SMLM by using true pairwise distance distributions, improving spatial reconstruction accuracy.

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

The paper characterizes S. zooepidemicus isolates from swine mortality outbreaks in the US, identifying genomic features linked to high mortality.