X. Huang

The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

The paper investigates auxin and GA signaling crosstalk in wild strawberry fruit initiation, revealing conserved and novel mechanisms through genome editing and network analysis.

This paper introduces an amorphous nickel-titanium alloy film as a new supporting substrate for cryoEM, showing improved electron conductivity and reduced beam-induced motion, leading to better particle distribution and resolution.

This study shows miR-214 reduces pulmonary angiogenesis and alveolarization in BPD by inhibiting PlGF and STAT3 signaling in hyperoxic rat models.

This study shows that neuronal lipolysis prevents lipid droplet accumulation and alleviates neurodegeneration in C. elegans by regulating PUFA partitioning and phospholipid incorporation.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

The paper investigates the DPO-VqmA quorum-sensing pathway in Vibrio cholerae, revealing DPO-dependent and -independent activities of VqmA and structural insights into ligand binding.

The paper shows STAT3 localizes in mitochondria-associated ER membranes, not mitochondria, and other mitochondrial TFs also localize to MAMs.

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

This study identifies Qtip as a phage-encoded antirepressor that disrupts prophage repressor function and localizes to bacterial poles, revealing distinct mechanisms of quorum-sensing activation.

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

This study investigates the transcriptome changes in grass carp brains under low temperature, identifying key pathways and genes involved in cold acclimation.

The paper identifies ACPT gene inactivation in toothless and enamel-less mammals and estimates its inactivation times across different lineages.

The paper shows that nanotopography induces dynamic changes in tight junction proteins by forming cytosolic complexes that regulate paracellular permeability.

This paper introduces a hydrogel beads platform for single-cell phenotyping and digital molecular detection, demonstrating its utility in analyzing genotype-phenotype correlations.

This study identifies miRNA193 in exosomes as a mediator of cisplatin resistance in esophageal cancer cells by regulating the cell cycle and inhibiting apoptosis.

This study challenges two established dogmas about bacterial cell growth and reveals a new linear relation between cell mass and division count across a wide range of growth rates in E. coli.

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

This study shows that loss of CHCHD2 and CHCHD10 activates OMA1, leading to mitochondrial cristae disruption similar to patient mutations, linking C10 pathogenesis to C2/C10 function.

This study investigates the role of ASK1/p38-mediated NLRP3 inflammasome signaling in diabetic retinopathy, showing its contribution to inflammation and aberrant retinal angiogenesis.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

The paper introduces VHUT-cryo-FIB, a workflow for preparing frozen-hydrated tissue lamella for cryo-ET, and demonstrates its effectiveness using rat and spinach samples.

This study characterizes the NF-κB protein in the sponge Amphimedon queenslandica, showing conserved features with vertebrates but distinct regulatory mechanisms.

This study quantifies selective pressures on human pigmentation genes across populations and time periods, finding directional selection on light and dark pigmentation traits.