X. Li

The paper builds a comprehensive Plant Virus Database (PVD) containing 3,206 virus species and 9,604 host interactions, revealing significant virome differences between plant groups and regions.

This study compares gene expression in Kaposi sarcoma tumors from skin and gastrointestinal tracts, identifying distinct and overlapping patterns of viral and host gene expression.

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

This study analyzes gene mutations in CHIKV E1 and E2 proteins from 2014 to 2019, identifying common mutation sites and their potential impact on immune escape and serological detection.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This study compares the effects of immunomodulatory BT peptide and antibiotics on cecal microbiota in broilers challenged with Clostridium perfringens, finding differences in microbial composition and function.

This paper introduces RLN, a deep learning method for 3D fluorescence microscopy deconvolution that improves speed, performance, and generalizability compared to existing methods.

The paper analyzes tumor mutation burden (TMB) across 5,000 cancer patients and finds a universal distribution pattern, with implications for cancer risk and treatment response.

This paper improves sample preparation and peptide separation for reduced peptide mapping-based MAM analysis of therapeutic monoclonal antibodies using Lys-C digestion, enhancing PQA monitoring for hydrophilic peptides.

This study identifies TraB1 as a novel EMCS component in Arabidopsis that regulates both ER-mitochondrial tethering and mitophagy, essential for mitochondrial function and stress recovery.

The paper develops a statistical mechanical theory to quantify intra-tumor heterogeneity using multi-region sequencing data, showing that ITH increases with spatial distance between regions.

This study shows that phosphorylation of DSB-1 by PP4PPH-4.1 and ATRATL-1 regulates meiotic DSB levels in C. elegans, with DSB-2 compensating for age-related inactivation of DSB-1.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This study develops a sequence-based functional metagenomics approach to discover novel CopA genes in environmental microbiomes, identifying 175 new sequences with functional validation.

The paper measures fitness costs of pfhrp2 and pfhrp3 deletions in malaria parasites using CRISPR/Cas9 and competition experiments, finding costs consistent with diagnostic selection driving their spread in some regions.

The paper investigates how mechanical feedback in growing tissue monolayers leads to dynamical memory effects through cell division and intercellular interactions.

The paper clarifies two strain rate calculation methods for TBI modeling and shows scheme-dependent results in experimental and FE model data.

This study identifies IZUMO1 as a unilateral gamete fusogen, showing it can induce cell fusion independently of JUNO binding.

This study examines how chronic intermittent hypoxia and chronic sleep fragmentation affect gut microbiota, serum metabolites, and tissue morphology in mice, revealing their impact on lipid metabolism.

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

The paper develops AI-powered IoT sensors for tracking mouse behaviors with 76.23% accuracy, addressing imbalanced data through sampling and feature selection techniques.

The paper identifies four alveolar macrophage superclusters in healthy bronchoalveolar lavage fluid using scRNA-seq and finds they are functionally specialized with conserved frequencies across individuals.

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

The paper examines ertapenem susceptibility in Neisseria gonorrhoeae isolates from Nanjing, China, showing increasing resistance over time and associations with specific genetic markers.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

This study shows that diet, particularly pollen polysaccharides, has a greater impact on shaping gut microbiomes in Asian honeybees than genetics.

This study shows deep learning can predict multi-omic biomarkers from H&E-stained cancer slides, with 50% of models achieving AUC > 0.633 across 32 cancer types.

This study develops a human brain organoid microphysiological platform to model immune-driven brain aging by perfusing aged monocytes and observing their effects on organoid tissues.

This study identifies BOS1 as a positive regulator of wounding-induced cell death and plant susceptibility to Botrytis cinerea, showing its role in both fertility and disease response.