X. Li

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

This study investigates how laser stimulation of endothelial-targeted nanoparticles increases blood-brain barrier permeability through calcium signaling and cytoskeletal changes.

The paper develops a red-shifted NanoLuc variant (QLuc) and uses it for in vivo immunobioluminescence imaging to improve deep-tissue visualization in mice.

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

This study constructs a comprehensive phylogenomic tree of butterflies and finds they originated in the Americas, diversified in the Paleotropics, and followed a 'cradle' pattern of dispersal.

This study shows Aspergillus tabacinus LZ-M can degrade acid red 73 anaerobically through a self-redox mechanism, mineralizing it to CO2 with a 90.28% decolorization rate in 5 days.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

This study shows that in C. elegans, D-2HG is produced via the propionate shunt and that loss of dhgd-1 causes embryonic lethality by disrupting ketone body metabolism, which can be rescued by vitamin B12 or 3-hydroxybutyrate.

This study characterizes fecal bacterial communities in dairy cattle across different management units, finding dynamic changes in diversity and composition.

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

Serum proteome profiling identifies subsets of long COVID patients with evidence of persistent inflammation and key immune signaling pathways.

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

This paper qualifies an improved multi-attribute method (MAM) for mAb identity, quality attributes, and new peak detection using Lys-C digestion and high-resolution MS.

This study compares transcriptomic and metabolomic responses to drought in two switchgrass genotypes, identifying specialized diterpenoids as key to drought tolerance.

This study identifies and analyzes bHLH transcription factors in Aquilegia, showing their potential roles in regulating petal nectar spur development through cell division and expansion phases.

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

This study identifies early urinary biomarkers in a rat model of multiple sclerosis and shows that early treatment with methylprednisolone reduces disease incidence.

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

A comprehensive mutational analysis of the catalytic domain of Arabidopsis CESA6 reveals distinct roles for conserved motifs in CSC vesicle trafficking, protein complex formation, or protein dynamics.

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

The paper identifies a C-terminal glutamine recognition mechanism by TRIM7 that targets viral proteins, revealing its role in antiviral defense against norovirus and SARS-CoV-2.