X. Liu

This study shows that higher tree species diversity enhances forest temperature buffering across multiple time scales, mediated by canopy density and structural diversity.

This study identifies LUZP1 as a regulator of actomyosin bundle assembly, showing its role in myosin II filament concatenation and stress fiber formation.

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

This paper introduces a novel fluorescence microscopy technique that combines super-resolution imaging with large field of view and long working distances using a ring-array illumination approach.

This study shows that turgor pressure in E. coli increases with growth rate and directly controls cell wall biosynthesis rate.

This study uses CRISPRi screens to identify genes affecting dalbavancin susceptibility in Staphylococcus aureus, revealing both known and novel factors.

This study analyzes whole genomes of African bushpigs and Malagasy bushpigs, revealing recent divergence and gene flow, challenging species boundaries and linking their arrival in Madagascar to human migration.

This study identifies UBAP2L's role in assembling functional nuclear pore complexes at the nuclear envelope by facilitating Y-complex formation and interactions with key nucleoporins.

The paper determines the structure of HIV-1 capsid hexamer bound to inhibitor 11l, revealing its binding mechanism and structural impact on the capsid protein.

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

This paper introduces TCIPs, molecules that activate cell death by rewiring cancer drivers, showing efficacy against DLBCL and potential for broader therapeutic applications.

This paper introduces a method to enable multicolor live-cell STED imaging with at least 4 colors using phasor analysis to separate dyes of the same spectrum.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

The paper identifies distinct FAP subpopulations in human musculoskeletal injuries that drive adipogenesis and fibrosis, showing that DLK1 downregulation promotes degeneration.

This study shows H2A.Z regulates plant salt response by modulating gene transcription, with its occupancy affecting gene expression levels under salt stress.

This study identifies NERCLIN as a mitochondrial protein that regulates cardiolipin homeostasis and ultrastructure, with implications for stress-induced mitochondrial adaptation.

The paper identifies a mechanism for seed size regulation through callose deposition/degradation at the phloem end of the ovule, mediated by β-1,3-glucanase genes.

This study identifies differentially expressed proteins in A. acidoterrestris under sublethal pH stress, revealing key acid resistance mechanisms involving pH homeostasis, metabolism, and DNA repair.

This paper develops Svg3, a cGAS-agonistic oligonucleotide, showing enhanced IFN-I responses and improved immunotherapy efficacy in preclinical models.

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

The paper identifies a conserved antigen, LafB, that provides serotype-independent protection against pneumococcal superinfection via Th17 cells, independent of antibodies.

The paper introduces aSRRF, a method that enhances SIM resolution to ~50 nm isotropically using image augmentation without changing the optical setup or sample acquisition.

This study investigates how inosine inhibits Alicyclobacillus acidoterrestris by damaging its cell membrane and affecting DNA replication and energy metabolism.

This study investigates how Myosin VI is trapped in its off-state, activated, and dimerizes through structural and functional analyses of its interactions with partners.

This study shows that SRSF2 mutations disrupt mitochondrial mRNA splicing, impair complex I function, and increase mitophagy through a PINK1 splicing mechanism, identifying mitophagy as a therapeutic target in MDS and AML.

This study compares two live-attenuated vaccines in hamsters, showing that B/HPIV3/S-6P induces stronger immune responses and better protection against SARS-CoV-2 variants than B/HPIV3/S-2P.

This study creates a single-cell transcriptional atlas of human lungs across ages, revealing age-related dysregulation in AT2 cells and their niche, including increased senescence and inflammation.