X. Liu

This study identifies a temperature receptor and miRNA pathway that mediates the seasonal morphological transition in Cacopsylla chinensis.

The paper identifies miRNAs in human islets and EVs that change under inflammatory conditions and can serve as biomarkers for type 1 diabetes risk.

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

This study uses coarse-grained simulations to investigate the conformational dynamics of 30S ribosomal subunit assembly in E. coli, revealing key roles of specific proteins in stabilizing the 16S rRNA structure.

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

This study models the evolution of gamete size and fertilization rates in switching environments, showing transitions from isogamy to anisogamy to oogamy through evolutionary branching and sexual conflict.

This study investigates the force generation and motility of Kinesin-14 motors HSET and KlpA, revealing they are non-processive motors with load-dependent power strokes and cooperative behavior.

This study identifies TRIP6 and LATS1 as novel components of the tension sensor complex at bicellular and tricellular junctions, revealing their distinct distribution and dynamics compared to α-catenin/vinculin.

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

This study identifies HMGB1 as a host defense molecule in the gut mucosal barrier that targets bacterial adhesins to prevent microbial invasion and adhesion.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This study identifies GTPBP8 as a critical factor for mitoribosomal assembly and mitochondrial translation, showing its depletion impairs subunit maturation and function.

This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.

This study uses vis-OCTF and TSA to image tree shrew retinal ganglion cell axon bundles in vivo, quantifying their dimensions and showing changes with distance from the optic nerve head.

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

This study identifies a PilO homolog in H. pylori that enhances soft-agar migration when cheV1 is deleted, suggesting a role in chemotaxis and motility regulation.

The paper identifies vacuolar H+-ATPase subunit a as the target of fluopicolide, an oomycete inhibitor, and suggests H+-ATPase as a novel fungicide target.

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

The paper compares mesenchymal-like gene expression programs in neuroblastoma preclinical models and patient tumors using single-cell RNA-seq and identifies chemotherapy-induced changes in PDX and GEMM.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

This study shows that the live attenuated Mtb vaccine candidate ΔLprG provides better protection than BCG in a low dose murine challenge model, reducing detectable infection and containing it anatomically.

This study shows Bacillus subtilis adapts genetically to different plant hosts and alternating host regimes, revealing both parallel and species-specific evolutionary patterns.

This study compares single-species and microbial consortium inoculation effects on biofertilization and bioremediation in soil, finding consortia more effective in field settings.