X. Ma

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This study generates new cell lines for undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor to better study sarcomagenesis and develop therapies.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

The paper identifies a novel SARS-CoV-2-related bat virus, PrC31, with complex recombination events and partial genetic similarity to SARS-CoV-2.

This study challenges the idea that hydrogen's antioxidant properties are its main biological function by showing limited hydroxyl radical scavenging and suggesting alternative mechanisms.

This paper develops a RHAMMB-targeting nanoparticle delivering siBcl-xL and KLA peptide to treat PNETs, showing synergistic tumor reduction in mice.

This study identifies PEAK3 as a pseudokinase that promotes cell migration and invasion through scaffolding interactions and tyrosine phosphorylation.

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.

The paper identifies genetic interactions in childhood cancers using a statistical pipeline, revealing 15 co-occurring and 27 mutually exclusive gene pairs, with most mechanisms linked to tumor subtypes or pathways.

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

The paper develops a kinetic model to study sRNA-mediated gene regulation, revealing co-transcriptional regulation and identifying binding as a rate-limiting step.

This study shows HIF-2 regulates intestinal ferritinophagy via NCOA4, which is essential for systemic iron homeostasis.

The paper identifies ubiquitylated proteins in Arabidopsis during MAMP-triggered immunity, revealing the ubiquitin-proteasome system's role in immune regulation.

The paper reports an unexpectedly high mutation rate in Thermococcus eurythermalis, challenges the hypothesis of low mutation rates in hyperthermophiles, and links mutation rate to genome size and population dynamics.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

This study screens herbal extracts against stationary phase Bartonella henselae and identifies five with antimicrobial activity, including Cryptolepis sanguinolenta, Juglans nigra, and Polygonum cuspidatum.

This study shows that increased CD44 expression in human skin and endometrial stromal fibroblasts, compared to other mammals, correlates with higher cancer vulnerability.

This paper identifies a novel sodium signaling complex involving NALCN and SLO2.1 channels that regulates uterine smooth muscle cell membrane potential and contractility.

This study shows that PAK3 kinase activity regulates the switch from tangential to radial migration in cortical interneurons by affecting cell shape and polarity.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper investigates mitochondrial lipid import in yeast, showing that di-unsaturated phosphatidylserine is preferentially imported for conversion to phosphatidylethanolamine, with ERMES and Vps39p facilitating this process.

The paper studies the binding and enzymatic activity of LD proteins using adiposomes, showing PI's effect on PLIN2 and ATGL.

The paper develops a fluorescent probe that changes emission lifetime upon aggregation, demonstrating potential for responsive imaging probes.

This paper engineers Escherichia coli to convert ethanol into acetyl-CoA and its derivatives through a heterologous pathway, achieving efficient ethanol consumption and production of PHB and prenol.

This study investigates the beampattern generated by resonance cavities in the Brown Long-Eared Bat and supports the hypothesis that frequency-driven sidelobe scanning arises from resonance in split cavities.

This study uses live-cell 3D single-molecule tracking to show that the NuRD complex decompacts chromatin and alters enhancer dynamics by increasing their movement and reducing time in a fast-diffusing state.

The paper develops a self-immobilizing NIR probe activated by SA-β-Gal for non-invasive imaging of senescence in mice.