X. Wang

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

This paper introduces tDKI to map cellular pathology in brain ischemia, showing it detects changes in cell morphology and membrane permeability in vivo.

The paper shows SwrA extends DegU binding over a UP element to activate flagellar gene expression in Bacillus subtilis, enabling motility and swarming.

This study identifies essential genes and genomic features of Xanthomonas citri using transposon mutagenesis, revealing insights into its genome organization and potential therapeutic targets.

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

This study shows macrophages form integrin-mediated adhesion rings to engulf surface-bound objects by local actin polymerization, not myosin II.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

This paper develops a CRISPR-Cas12a-based method for detecting Schistosoma japonicum circulating nucleic acids with high sensitivity and specificity, validated using rabbit serum samples.

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

The paper identifies TDIF ligand-activated PXY receptors and CAIL transcription factors as key to defining cambium stem cell identity in Arabidopsis roots and explains their positioning mechanism.

This paper analyzes the ecological diversity and evolution of Enantiornithes by introducing new data on Bohaiornithidae and integrating it with existing data on other enantiornithine families.

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

This study shows FoxP3 forms multimers to bridge DNA through TnG repeats, revealing a new DNA recognition mechanism involving microsatellites.

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

This paper designs vaccines targeting misfolded alpha-synuclein by mimicking its fibril structure, inducing antibodies that recognize pathological forms without reacting to native protein.

The paper develops a machine learning framework to create organ-specific gene expression datasets and infer gene regulatory networks, achieving high accuracy in predicting transcription factors regulating organ-specific processes.

SoyDNGP is a deep learning framework for genomic prediction in soybean breeding that outperforms existing methods in accuracy and efficiency, with a web interface for trait prediction and lookup.

The paper uses the GH model to analyze genetic drift in mammalian rDNA genes, finding that fixation times are faster than expected, suggesting stronger drift or adaptive evolution.

The paper shows that intraspecific genetic variation significantly affects toxicity responses to microcystins in Daphnia magna, highlighting the need for diverse genotypes in environmental risk assessments.

This paper improves DNA structure design by introducing a new base pair alphabet with P-Z pairs and thermodynamic parameters, enhancing design accuracy and reducing off-target folding.

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This study identifies FOXK2 amplification and overexpression in breast cancer, showing its role in promoting tumor growth, chemoresistance, and synergistic therapeutic responses when targeted with PI3KCA inhibitors.

This study shows that metabolic changes in ticks affect their fitness and interactions with microbes, highlighting the role of BAIBA in these relationships.