X. Wang

This study shows that myeloperoxidase (MPO) activity in atherosclerotic plaques predicts atherothrombosis in rabbits and correlates with ruptured human atheroma.

This study uses landrace diversity in wheat to identify genetic resources for climate resilience and improved traits, providing a framework for crop improvement.

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

This study shows that SARS-CoV-2 N protein reduces Dicer, XPO5, SRSF3, and hnRNPA3, leading to pneumonia, and that inhibitors can reverse this effect.

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

This study evaluates the inhibitory activity of the HY3000 peptide against emerging SARS-CoV-2 variants EG.5, EG.5.1, and BA.2.86, finding it retains potent antiviral effects.

The paper identifies T cell subtypes, particularly Treg and Tfh, in testicular germ cell tumors and suggests their role in tumor progression and immunotherapy.

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

This study shows EZH2 deletion in adult acinar cells does not block regeneration but limits PDAC progression by altering the tumor microenvironment and differentiation.

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

The paper introduces MAGPIE, a computational method to identify driver mutations in cancer pathways by analyzing mutual exclusivity patterns, and validates it on melanoma data.

This study shows ER fusion proteins in breast cancer cell lines drive ligand-independent pro-oncogenic pathways, with subtype- and fusion-specific effects.

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

The study identifies ocean warming and nutrient availability as key drivers of equatorial marine extinctions during the Permian-Triassic mass extinction using geochemical and fossil data from the Meishan section.

This study uses single-cell RNA sequencing to identify cycling alpha cells as key beta cell progenitors in response to DYRK1A inhibitor treatment in human pancreatic islets.

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

SenePy identifies cell-type specific senescence signatures from single-cell data, improving senescent cell detection in vivo and revealing increased senescence in diseases like COVID-19 and myocardial infarction.

This study assesses PFAS levels in fish from Illinois waterways, finding elevated concentrations in specific areas and species, with implications for human health risks through fish consumption.

This paper introduces a method to enhance spatial resolution in lipid mass spectrometry imaging of mouse brain tissue by using a swellable polyelectrolyte gel, achieving subcellular-level visualization.

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

This study analyzes whole genomes of African bushpigs and Malagasy bushpigs, revealing recent divergence and gene flow, challenging species boundaries and linking their arrival in Madagascar to human migration.

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.