X. Zhang

The paper reports the cryo-EM structure of the human TIM22 complex at 3.7 angstrom resolution, revealing its architecture and potential mechanism for protein import.

This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.

This paper shows that increasing cryo-EM sample freezing temperature reduces beam-induced motion and improves reconstruction resolution by including more undamaged initial frames.

This study identifies SCR's role in promoting root growth by enhancing cell elongation and maintaining redox homeostasis through suppression of oxidative stress response.

This study shows that motorized shoes can induce locomotor adaptation similar to split-belt treadmill training, suggesting portable devices can study sensorimotor adaptation outside the lab.

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

This study shows that Klf5 downregulation in VSMCs leads to mitochondrial fission and senescence by reducing eIF5a, which preserves mitochondrial integrity.

This study shows that P16 methylation increases cancer cell sensitivity to palbociclib, a CDK4/6 inhibitor, through experimental and pharmacogenomic analyses.

This study shows that the in vitro and in vivo cellular uptake and trafficking of miktoarm copolymer nanomicelles (MCNs) correlate, with FRET efficiency changes reflecting transport mechanisms and probe uptake behavior.

The paper identifies a lipid-dependent phosphorylation cascade involving PDK1 and D6PK that regulates PIN-mediated auxin efflux in Arabidopsis development.

This study investigates how temperature affects RNA editing in grape organelles, finding that editing levels decrease with rising temperature and that PPR gene expression declines, potentially contributing to stress adaptation.

The paper examines ovule development in Cycas and Zamia, identifying a previously unrecorded nucellar beak in Zamia that may function as a pollen receptor.

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

The paper uses single-cell RNA-seq to analyze human Wharton’s Jelly-derived MSCs, identifying heterogeneity in gene expression and potential marker genes for potency.

This study develops an efficient CRISPR/Cas9 method for integrating a large transgene cassette into the CEP112 locus in pigs, achieving successful expression of microbial enzymes in salivary glands.

The paper investigates how entomopathogenic nematodes develop resistance to benzoxazinoid metabolites sequestered by a maize herbivore, showing increased infectivity towards the herbivore.

This study shows that neogambogic acid inhibits osteosarcoma by targeting the USP9x/SOX2 axis through ubiquitin proteasome-mediated degradation of SOX2.

The paper analyzes 2045 MAGs from activated sludge to identify plant- and environment-specific features using machine learning, achieving 96.6% accuracy in distinguishing AS MAGs from others.

This study shows lung cancer exosomes promote MDSC expansion via miR-21a/PDCD4/IL-6/STAT3 pathway, enhancing tumor growth.

This study conducts a meta-analysis showing opioids increase fracture risk by 78% in patients with chronic noncancer pain.

The paper presents the structure of nucleotide-bound Tel1ATM, revealing molecular mechanisms of inhibition and explaining disease-related mutations.

The paper predicts and validates common neoantigens in colorectal cancer that are both presented and immunogenic, identifying potential universal targets for immunotherapy.

The paper identifies a plant MLKL protein family structurally similar to vertebrate MLKL, which provides immunity against pathogens without inducing cell death.

The paper identifies proteasome-dependent degradation of PAL as a mechanism linking glucosinolate and phenylpropanoid biosynthesis through regulation of KFB genes.

This study shows that activating or inhibiting PPAR-mediated fatty acid β-oxidation does not promote cardiomyocyte proliferation in adult mice, either under normal conditions or after myocardial infarction.

The paper develops a convergent hybrid phase ligation strategy for synthesizing large proteins, demonstrating its effectiveness with the 212-residue histone H1.2.

This study shows glycogen metabolism via the oxidative pentose phosphate pathway (OPPP) initiates photosynthesis in cyanobacteria by modulating NADPH levels during dark-light transitions.

The paper introduces a presuppositionless method to analyze single nanoparticle trajectories by leveraging their historical data, revealing spatiotemporal patterns without predefined models.

This study identifies a novel O_SCPCAPLC_SCPCAP-serine exporter, SerE, and its positive regulator NCgl0581 in C. glutamicum, showing their roles in amino acid export and transcriptional regulation.