X. Zhang

This study identifies a sulfate-reducing bacterium that forms zero-valent sulfur through sulfide oxidation, highlighting a new pathway in the sulfur cycle.

The paper identifies Neanderthal introgression variants that influence gene expression in response to environmental perturbations and validates their regulatory function.

This study examines factors driving radiating diversification in Saussurea using Miocene to present data, finding increased diversification rates linked to climate fluctuations and adaptive traits.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study shows that influenza A and D viruses interfere with each other during coinfection based on the timing and order of infection, with proinflammatory responses playing a key role.

This study challenges the idea that hydrogen's antioxidant properties are its main biological function by showing limited hydroxyl radical scavenging and suggesting alternative mechanisms.

The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.

The paper shows the N501Y spike mutation in SARS-CoV-2 enhances viral transmission in hamsters and human airway cells by increasing receptor binding affinity.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

This study compares the infectivity and pathogenicity of SARS-CoV-2 variants B.1.1.7 and B.1.351 to early 2020 strains in Syrian hamsters, finding similar disease outcomes but stronger proinflammatory cytokine elevation in B.1.1.7 infections.

This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.

This study uses mass cytometry to analyze immunological changes in mice after radiation-induced cardiac fibrosis, finding increased macrophages and pro-fibrotic cytokines.

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

This study shows that loss of ARID1A increases mitochondrial metabolism in OCCC and that inhibiting mitochondrial complex I improves survival in preclinical models.

This paper reports a unique enzyme, LplA, that forms a stimuli-responsive and reversible hydrogel with catalytic activity, revealing its structural and functional mechanisms.

This study identifies hnRNP K overexpression in AML and shows it causes myeloproliferative disease in mice by altering RUNX1 splicing.

This study investigates the assembly of 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes with the E2o core using HDX-MS and CL-MS, revealing differences in binding modes between hE1o and hE1a.

Nelfinavir reduces SARS-CoV-2-induced lung pathology in Syrian hamsters without affecting viral RNA or infectious titers.

This study identifies cluster-specific gene markers for Shigella and EIEC strains and develops a tool, ShigEiFinder, to accurately differentiate and serotype them with high accuracy.

The paper presents a 3D computational framework for modeling biomembrane deformations using Kirchhoff-Love kinematics, demonstrating its ability to capture non-axisymmetric deformations and symmetry-breaking behaviors.

The paper evaluates the neutralization effect of BNT162b2 vaccine-elicited sera against SARS-CoV-2 variants with specific spike mutations.

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

This paper develops a trans-complementation system to produce single-round infectious SARS-CoV-2 at BSL-2 labs, enabling safe high-throughput testing without full viral replication.

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

This study determines cryo-EM structures of GLP-1R-Gs complexes bound with semaglutide and taspoglutide, revealing similar peptide binding modes but distinct 3D motions compared to GLP-1.

This study validates stable GPCR:Gs complexes without Nb35 stabilizers and evaluates 200kV vs 300kV cryo-EM imaging for drug discovery.

This study determines the structural basis of K+ transport by KdpFABC using cryo-EM, revealing a pathway and mechanism involving conformational changes in KdpB and a static KdpA.

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.