X. Zhou

This study reveals how GTP cycling gates CTP synthase activation through three sequential checkpoints, linking GTP binding and dissociation to catalytic steps in CTP synthesis.

This study identifies BNIP3 as a mediator of DNA damage response signaling to mitochondria, which promotes senescence by altering mitochondrial structure and metabolism to increase p16 expression.

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

This study identifies PlAvh202, an RXLR effector from Peronophythora litchii, which enhances plant susceptibility by destabilizing SAMS and suppressing ethylene production.

The paper identifies RpoA, an RNA polymerase α-subunit, as a novel factor enabling quorum sensing reprogramming in Pseudomonas aeruginosa LasR-null mutants.

The paper introduces a method to label and profile subcellular proteins in living cells using a genetically encoded photocatalyst and reactive probes, achieving high specificity in mitochondrial proteome analysis.

This study maps the global distribution of antibiotic resistance genes in soils and identifies key environmental drivers influencing their prevalence.

This study determines the structure of hPRPS2 polymers using cryo-EM, revealing how ADP binding affects polymerization and catalytic activity.

This study shows that CMA deficiency in mesenchymal cancers promotes tumor growth via TGFβ signaling and metabolic rewiring.

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

This paper introduces wide-field plasmonic thermal microscopy (W-PTM) for rapid local temperature regulation and demonstrates its use in modulating TRPV1 ion channels in living cells.

The paper reports the first crystal structure of a coronavirus M protein from batCOV5 and identifies its interaction with the N protein.

The paper investigates how insulin signaling and anti-insulin mechanisms in ants link reproduction to extended longevity through gene expression analysis in different castes.

This study evaluates simultaneous and sequential multi-species coronavirus mRNA vaccination, showing sequential vaccination induces stronger antibody responses against SARS-CoV-2, SARS-CoV, and MERS-CoV.

This study investigates the redundant functions of YTHDF proteins, showing that YTHDF1 and YTHDF2 have distinct roles in RNA decay and condensate formation, and that RNA stabilization after YTHDF depletion is m6A-independent.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

The paper investigates two filament structures of E. coli PRPS resolved by Cryo-EM, revealing how ligand binding modulates allosteric inhibition and PRPP production.

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

The paper tests two chimpanzee adenovirus vectors expressing SARS-CoV-2 spike or nucleocapsid proteins in hamsters, finding that combining them enhances protection against COVID-19.

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

This study shows that IRE1 RNase activity regulates CD95 expression and cell death in cancer cells, with implications for therapeutic targeting.

This study tests two distinct chimpanzee adenovirus vectors expressing SARS-CoV-2 spike protein in mice, showing antibody induction and cross-reactivity between variants.

This study shows that heat-acclimated mice have more Tregs, which reduce inflammation and improve heat tolerance through the PD-1/PD-L1 pathway.

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

This paper uses human ventricular electromechanical modelling to explain clinical phenotypes in acute and chronic myocardial infarction, showing that ionic remodelling impacts ECG changes and ejection fraction.

This paper introduces single-objective evanescent scattering microscopy for label-free single protein imaging and binding kinetics quantification with high spatiotemporal resolution.

This study examines concurrent tau pathologies in FTLD-TDP, finding common co-occurrence of PART and ARTAG, and rare cases of AGD and CBD.