Y. Cao

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

This paper develops a method using gold nanoclusters to deliver siRNA into plant cells, achieving efficient gene knockdown with minimal toxicity.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

The paper shows that morphogenesis in multi-layered tissues is self-organized by interfacial mechanical interactions that create compression gradients, leading to stratification or 2D morphogenesis depending on tissue fluidity.

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

The paper shows PRMT1 maintains neural stemness by coordinating ribosomes and proteasomes through arginine methylation, preventing degradation and supporting protein homeostasis in cancer and neural stem cells.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

This study uses molecular dynamics simulations to analyze the structure, dynamics, and antibody binding of the fully-glycosylated SARS-CoV-2 spike protein, revealing key roles of glycans in stabilizing RBD conformations and antibody epitope exposure.

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

The paper describes the development and evaluation of a 10-color Xpert MTB/XDR assay for rapid detection of drug resistance in tuberculosis directly from sputum samples.

This study identifies soxS as a genetic target for reversing multi-drug resistance in K. pneumoniae by analyzing its oxidative stress regulon and demonstrating its role in efflux pump regulation and tetracycline susceptibility.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

The paper models and simulates a fully-glycosylated SARS-CoV-2 spike protein in a viral membrane using computational methods and provides the structures for research on COVID-19 prevention and treatment.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study investigates ion and water permeation mechanisms of the SARS-CoV-2 E protein channel using in silico methods, revealing hydrophobic gates and voltage-dependent behavior.

This study predicts lncRNA-encoded small peptides in glioma and analyzes their oligomer channel function using in silico methods.

This study models antibody-target binding dynamics in tumors using BRET imaging and finds spatial differences in cetuximab binding to EGFR.

This study introduces a quantitative metric to evaluate therapeutic antibody doses and identifies factors influencing dose selection beyond traditional pharmacokinetics and target binding affinity.

This study develops a mechanistic model to quantify T2DM progression, showing that early diagnosis and intervention are critical for preserving beta-cell function and glycemic control.

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

The paper identifies 56 beneficial genes for optimizing free fatty acids production in E. coli using CRISPRi-Omics and reports a record FFAs titer of 21.6 g L-1.

The paper identifies how TGF-β signaling inhibition allows GATA4 to interact with JMJD3, promoting cardiomyogenesis by demethylating H3K27me3 at cardiac gene promoters.

This study develops a method to mature hiPSC-CMs, enabling them to model adult-onset cardiovascular disease like hypertrophic cardiomyopathy.

This study identifies how abnormal nitration and S-sulfhydration of the Sp1-CSE-H2S pathway contribute to the progression of hyperhomocysteinemia through a self-reinforcing cycle.

The paper describes the isolation and genomic characterization of a novel Yersinia species from a human yersiniosis case.

This study presents a biochemical reaction-diffusion model coupled to cell mechanics to explain how cells switch between migration modes through phase transitions.