Y. Cao

This study shows metformin lowers IOP and protects trabecular meshwork from oxidative damage by activating integrin/ROCK signaling in both in vivo and in vitro models.

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

This study investigates TANGO2 deficiency in iPSC-derived cardiomyocytes and fibroblasts, finding no defects in mitochondrial OXPHOS function under baseline or fasting conditions.

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

The paper identifies a Cdh3-Lam332 signaling axis in a subset of leader cells that drives protrusion dynamics and collective migration in tumor organoids.

This paper develops a biosensor system to monitor cell-cell interactions induced by therapeutic antibodies in 3D cultures, showing faster NK cell interactions compared to T cells.

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

This paper develops a predator-prey model to simulate tumor-immune interactions and immunotherapy response using preclinical and clinical data.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This study constructs multiscale models of SARS-CoV-2 using coarse-grained molecular dynamics simulations and experimental data, revealing dynamic behavior of membrane proteins and lipid interactions.

This study quantifies how Omicron variant's RBD mutations enhance binding affinity to ACE2 compared to the original SARS-CoV-2 strain.

This study shows that sole NH4+ supply reduces photosynthesis in Lonicera Japonica by decreasing mesophyll conductance, driven by thicker cell walls and reduced chloroplast surface area.

The paper shows that neural stemness unifies tumorigenicity and pluripotent differentiation potential by demonstrating SETDB1's role in maintaining these properties through epigenetic and transcriptional mechanisms.

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

This study shows that myofibroblast senescence in aged infarcted rabbit hearts promotes arrhythmogenic remodeling by coupling with myocytes and prolonging action potential duration.

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

This study uses molecular dynamics and experiments to analyze how mutations in SARS-CoV-2 variants affect their binding to ACE2, identifying which variants are more contagious.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

This study identifies residue networks mediating allosteric communication from the Ang II binding site to Gq and β-arrestin2 coupling sites in AT1R, revealing shared and distinct residues that could guide biased ligand design.

This study identifies the roles of histone acetyltransferases and deacetylases in the growth, virulence, stress resistance, and DNA repair of Alternaria alternata through gene deletion mutants.

This study uses molecular dynamics simulations to analyze SARS-CoV-2 spike protein interactions with antibodies, revealing structural dynamics and mutation impacts on neutralization.

The paper presents autopsies of Covid-19 patients showing pulmonary stromal expansion and intra-alveolar coagulation as primary causes of death, with virus replication in pneumocytes and macrophages.

This study profiles co-transcriptomes of Arabidopsis and its associated bacteria to understand molecular interactions and bacterial adaptation mechanisms.