Y. Chen

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

This paper introduces a method to genetically incorporate a nonhydrolyzable phosphotyrosine analog into mammalian proteins to study tyrosine phosphorylation without dynamic interconversion complications.

This paper develops a microfabricated invasion assay for ovarian cancer spheroids to study tumor invasion and drug response.

This study identifies and classifies 25,498 gamma-type Env-containing ERVs in anamniotes, revealing genetic diversity and evolutionary patterns through phylogenomic analysis.

The paper uses molecular dynamics simulations to analyze how three imidazoquinoline agonists selectively bind to TLR7 and TLR8, revealing van der Waals interactions as key to their selectivity.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study shows that nebulized NIH-CoVnb-112 nanobody reduces weight loss, viral burden, and lung pathology in Syrian hamsters infected with SARS-CoV-2.

This study develops plasmon-enhanced nanodiamonds (PEN) for biological imaging by using DNA self-assembly to improve brightness and temporal resolution of NV centers.

This study reveals the structural mechanism of ATP8B1 activation by substrate binding, showing an autoinhibited state that is released upon phosphatidylserine binding.

This study identifies EC Rap1B as a key mediator of vascular immunosuppression by promoting T-cell exclusion and tumor growth through regulation of CAMs and NFκB signaling.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

The paper identifies a novel teneurin/TCAP-LPHN system that regulates skeletal muscle contractility and fatigue through insulin-independent glucose importation and cytosolic Ca2+ signaling.

This study identifies dysregulated eIF4F translation initiation complex in HS lesions, linking it to SCC development through Cyclin D1 and c-Myc overexpression.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study identifies CsMYB4a as a multifunctional transcription factor that regulates the auxin signaling pathway and phenylpropane/lignin pathways in Camellia sinensis.

The paper determines the cryo-EM structure of the yeast TIM complex, revealing that Tim17 forms the protein translocation path while Tim23 provides structural support.

The paper develops SSR markers from drought stress-responsive miRNAs in Dongxiang wild rice and verifies their genetic diversity across DXWR and modern rice varieties.

The paper introduces a multi-camera array microscope (MCAM) that enables high-resolution, multi-scale imaging of behavior and neural activity in model organisms.

This study presents the nuclear genome of a pedinophyte green alga, revealing genome streamlining and expansion in different lineages of Chlorophyta.

This study identifies GpsB's role in coordinating cell division and wall teichoic acid biosynthesis in Staphylococcus aureus through interactions with PBPs and the WTA export complex.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This paper reports cryo-EM structures of human ABCD1 in different states to elucidate its mechanism of substrate recognition, translocation, and release.

The paper identifies a new substrate recognition site in the mitochondrial ADP/ATP transporter AAC, revealing its role in ADP selectivity and transport mechanism.

This study compares antibody durability and breadth after SARS-CoV-2 infection and vaccination, finding that infection-induced antibodies show greater long-term stability and cross-variant breadth.

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

This study acquires and analyzes the macromolecular MR spectrum in healthy adults across ages 20-69, finding no significant age or sex-related changes in macromolecule signals.

This study develops genome-wide lncRNA-derived SSR markers for Dongxiang wild rice and validates their polymorphism and utility in genetic diversity analysis and breeding.

The paper reveals how assembly status transitions in glutamine synthetase modulate enzymatic activity through dynamic allosteric regulation.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.