Y. Chen

This study presents the structures of human KCC2 and KCC3, including phosphorylation and inhibitor-bound forms, revealing mechanisms of regulation and potential drug targets.

This study engineers Pseudomonas putida to produce indigoidine with high titer, rate, and yield by coupling product formation with growth through metabolic rewiring and CRISPRi knockdowns.

This study reports a randomized trial using intranasal mechanical stimulation to reduce ME symptoms by 30% and identifies immune correlates of improvement, suggesting disease tolerance failure as a potential mechanism.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study shows a recombinant adenovirus vaccine protects rhesus macaques from SARS-CoV challenge by inducing immune responses and reducing lung damage.

This study shows that the type VII secretion system in Staphylococcus aureus protects against host antimicrobial fatty acids by maintaining membrane integrity and lipid homeostasis.

This study identifies suppressor mutations in Bacillus subtilis that alleviate YpsA-mediated cell division inhibition, revealing YfhS's role in cell size regulation.

The paper develops a CRISPR/Cas9 HITI system for precise, safe harbor locus integration of multi-modality reporter genes for cell tracking.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

The paper analyzes the evolution and variation of 2019-nCoV by comparing genomic sequences from multiple isolates, identifying amino acid variations and estimating the molecular clock and most recent common ancestor.

The paper develops a pipeline to detect mutations from RNA-seq data in breast cancer and shows it can identify mutations in key genes and pathways in 86.8% of tumors.

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

This study characterizes longitudinal immune system variation in 99 adults over one year, finding that variability is an individual feature linked to metabolic health markers.

This study shows that PKA activation reduces self-renewal of the basal compartment, leading to less aggressive mammary tumors with increased chemotherapy sensitivity.

The paper creates a high-resolution global root biomass map using field measurements and environmental data, finding lower root biomass than previous studies due to improved methods and data.

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This paper develops a conditional expression strategy to enable mature B cell expression of bnAb precursors in transgenic mice, overcoming developmental blocks caused by bnAb properties.

This paper introduces a dual-color z-scan fluorescence technique to improve detection of plasma membrane protein binding in living cells, revealing cooperative binding of HIV-1 MA and altered binding of fibroblast growth factor receptor substrate 2 mutants.

This study identifies human lncRNA metabolic regulators (hLMRs) using integrative transcriptome analyses and humanized mouse models, validating one hLMR's role in cholesterol metabolism.

The paper uses live cell imaging to show clathrin-coated pits develop curvature early without requiring a flat-to-curved transition.

The paper develops a method to measure multiscale chromatin folding and nuclear structures in single cells, revealing cell-type-specific architectures and physical principles of chromatin organization.

The paper develops a mathematical framework to analyze the stability of multicomponent membranes, showing how glycolipids stabilize phospholipid membranes through energy considerations.

This paper introduces a novel in vitro system to maintain Varroa destructor mites on artificial diets and demonstrates their ability to acquire and transmit honey bee viruses.

The study shows cycloheximide arrests cells in G2 phase due to p38 MAPK activation, not protein synthesis inhibition, indicating G2 protein synthesis is not required for mitotic entry.

This study shows that flagellum malfunctions in Euglena gracilis trigger metaboly, an escape strategy used to avoid restrictions and restore flagellar function.

This study combines mechanistic and machine learning models to optimize tryptophan metabolism in yeast, achieving a 106% increase in tryptophan accumulation through predictive engineering.

This paper uses UAS to model maize growth and identifies temporal QTL associated with plant height, showing dynamic expression patterns over time.

This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.