Y. Chen

This study determines the structure of S. aureus GpsB's N-terminal domain, revealing its interaction with FtsZ and PBP4, and shows its essential role in cell division.

The paper identifies Mj-NEROSs, an effector from root-knot nematodes, which suppresses plant immunity by interacting with ISP in plastids to reduce ROS production.

A low carbohydrate diet suppresses neuroendocrine tumor onset and progression by reducing insulin signaling and PI3K-Akt-mTOR pathway activity in mouse models and correlates with better prognosis in patients.

This study describes a new saurosphargid species from the Early Triassic of South China and presents a phylogenetic analysis clarifying the relationships of sauropterygians and their evolutionary history.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

The paper analyzes divorce rates in birds using phylogenetic methods and finds male promiscuity and migration distance correlate with higher divorce rates.

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

This study identifies YTHDF1 as an oncogenic m6A reader promoting AML by enhancing oncogenic translation and shows tegaserod inhibits its function.

This study identifies MRC's organ-specific roles in regulating starch granule initiation in wheat leaves and endosperm, showing it promotes leaf granules but delays endosperm B-type granule initiation.

This study identifies Rap1's role in coordinating cell-cell adhesion and cytoskeletal reorganization during collective cell migration in Drosophila embryos.

The paper identifies three Pseudomonas putida isolates with diverse pentose catabolism capabilities and characterizes their genes and pathways for xylose and arabinose oxidation.

The paper uses FRET nanosensors to study lactate and glucose metabolism in retinal Müller cells, revealing MCT2 and MCT4 expression and metabolite flux dynamics.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study identifies distinct in vivo properties and functions of large and small extracellular vesicles in breast cancer, showing their differential biodistribution and tumorigenic potential.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study examines how socioeconomic status across the life course affects BMI trajectories and obesity risk in China using longitudinal data from the China Health and Nutrition Survey.

The paper identifies independent hard selective sweeps in two Colorado potato beetle populations linked to insecticide resistance, suggesting rapid and repeated adaptation to pesticides.

This study compares epigenomic and transcriptional changes in active and latent HIV-1 infection of SupT1 cells, finding broader alterations in latent infection affecting both protein-coding and long non-coding RNAs.

This study uses a yeast-based system to identify nirmatrelvir-resistant mutations in SARS-CoV-2 Mpro and confirms findings with structural analysis.

The paper investigates the combined effects of eight heavy metals on Bacillus cereus, revealing global iron starvation responses not observed with individual metals.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

The paper identifies redundant medium components in iPSC differentiation to microglia using single-cell RNA sequencing and provides an optimized protocol for generating functional microglia.

This study identifies EFNA4 amplification as a driver of lung adenocarcinoma lymph node metastasis through genomic analysis and functional experiments.

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

This study identifies mce3R mutations causing contezolid resistance in Mycobacterium tuberculosis by increasing Rv1936-mediated drug degradation.

This study shows tegaserod maleate inhibits gastric cancer growth by targeting MEK1/2 in vitro and in a mouse model, with effects comparable to trametinib.

The paper characterizes the genomic and transcriptomic landscape of MDA PCa PDX models and develops an organoid platform to study prostate cancer heterogeneity and resistance.