Y. Chen

This study identifies NCR343 and NCR-new35 as essential NCR peptides required for maintaining rhizobia in nitrogen-fixing nodules of M. truncatula.

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

The paper uses ex vivo perturbations on human lung slices combined with single-cell RNA-seq to study fibrogenesis, showing similarities to in vivo cell circuits and drug effects.

The paper introduces a modular prime editing system called SunTag-PE that improves delivery efficiency without compromising editing efficiency.

This study investigates the relationship between breast cancer and gut microbiome by analyzing fecal samples from mice with induced breast tumors, finding changes in microbial composition and signaling pathways.

This study identifies OPCs and punicalagin as potent inhibitors of SARS-CoV-2 infection, with punicalagin showing the strongest activity against omicron variants and viral entry.

This study compares force-induced conformational changes in integrin ectodomains α5β1 and αVβ3, revealing distinct mechanical behaviors and energy landscapes.

The paper identifies CD4+CD28- cytotoxic T cells in SLE patients and shows IL-15 enhances their expansion and cytotoxic function, with JAK3 inhibition blocking this effect.

This study identifies HERC5-catalyzed ISGylation of cGAS as a mechanism that enhances antiviral innate immunity by modulating the cGAS-STING pathway.

This study determines the structures of human ABCC4 in apo and complexed forms, revealing its role in exporting platelet agonists and inhibitors, and identifying a pocket for drug design.

The paper studies fibroblast organization and proliferation on substrates with topological defects using simulation and experiment, finding that division rates depend on cell area and aspect ratio.

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

This study identifies LjPup1 as a cytokinin exporter in root nodules that coordinates shoot growth with nitrogen fixation by exporting active cytokinins.

This study develops a mathematical model to explain how Myxococcus xanthus uses mechanosensing during gliding motility to coordinate cell reversal frequency and multicellular pattern formation.

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study shows that MC1R agonist reduces scarring and improves healing in a chronic wound model by enhancing angiogenesis, lymphangiogenesis, and reducing inflammation.

The paper isolates and characterizes a novel lytic vibriophage, R16F, which shows potential as a biocontrol agent against V. parahaemolyticus due to its specificity and lack of virulence factors.

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

This study uses a computational model to show that ventricular systolic function affects thrombus formation after EVAR, with specific correlations identified.

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

This study shows that pyruvate-conjugated PEGylated liposomes enhance uptake in retinal photoreceptors, reducing cell death in degeneration models compared to free drugs.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

This study identifies ESCRT-III homologs in magnetotactic bacteria, showing their role in membrane remodeling and multicellular morphogenesis through genomic and imaging analyses.

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

The paper was withdrawn due to duplicate posting and is no longer available for citation.

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

The paper designs and characterizes a protein fold switching network where single amino acid substitutions can switch fold and function in proteins.