Y. Chen

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

The paper analyzes aging and cancer by profiling ubiquitinome and RNA-seq data in mice, identifying H2A ubiquitination as a marker linked to prognosis and tumor microenvironment.

The paper tests if phylogenetic conservatism improves seed germinability prediction models in shortgrass prairie species and finds it does not.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This paper develops a method using chiral derivatization and TIMS-MS to separate and visualize 19 pairs of chiral amino acids in complex biological samples.

The study identifies SARS-CoV-2 Mpro mutations associated with nirmatrelvir resistance from clinical isolates.

This paper demonstrates a method to distinguish and quantify chemically similar small molecules using electrochemical aptamers by tuning surface charge.

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

This paper investigates retinal energy metabolism, revealing that photoreceptors use distinct metabolic pathways, including the mini-Krebs, Cahill, and Cori cycles, to uncouple glycolysis from oxidative phosphorylation.

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

The paper identifies bacteriophage nucleotidyltransferases and anti-TIR defense genes that inhibit TIR-STING immune responses to promote viral propagation.

The paper identifies a conserved membrane protein that negatively regulates Mce1 complexes in mycobacteria by inhibiting transporter assembly.

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

This study identifies a toxin-mediated policing system in Bacillus that punishes phenotypic cheaters, enhancing population fitness in plant rhizosphere and under stress.

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

This study uses scRNA-seq and scTCR-seq to analyze virus-specific CD4+ T cells during chronic LCMV infection, identifying distinct transcriptional states and clonal diversity.

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.

This study shows that Varroa destructor mites vector Deformed wing virus (DWV) with varying efficiency depending on their phoretic stage and the DWV type they transmit, with DWV-B reducing mite lifespan.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

This study compares transcriptomic and metabolomic responses to drought in two switchgrass genotypes, identifying specialized diterpenoids as key to drought tolerance.