Y. Du

This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

The paper identifies synergistic drug combinations for T-ALL using high-throughput screens and develops lipid nanoparticle formulations that maintain drug synergy and improve anti-leukemic activity.

This study shows that Siah1a/2 ubiquitin ligases regulate alveolar macrophage differentiation, and their loss promotes lung adenocarcinoma by increasing immature macrophages and pro-tumorigenic inflammation.

This study identifies Tex2 as a tubular ER protein required for lysosomal functions through its interaction with TMEM55 at ER-LE/lys MCSs.

This study compares thermal stress responses and transcriptomic profiles of different shell colour morphs in the snail Batillaria attramentaria, finding that dark morphs exhibit preparative defense strategies and higher cardiac thermal tolerance.

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

The paper shows that gut microbiota balance immune responses in neonatal lungs, promoting recovery from pneumonia by modulating tissue repair and inflammation.

This study investigates the mechanical deformation and structural properties of ligated DNA crystals using simulations and experiments, revealing complex behaviors not predictable from individual components.

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

This study shows that ATFS-1's mitochondrial localization, not its nuclear activity, is essential for mtDNA recovery and development after starvation in C. elegans.

This study shows that corneal stromal stem cell secretome promotes scarless corneal wound healing and rescues sensory nerves by reducing inflammation, fibrosis, and complement-mediated cell death.

This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.

This paper describes a method using calcineurin fusion to improve cryo-EM structure determination of Family A GPCRs by enhancing particle alignment.

This study identifies versican as a collagen-binding protein that regulates collagen matrix organization and mechanics through its G3 domain.

This study shows that Numb is essential for skeletal muscle function, as its knockout reduces force, alters mitochondrial structure, and affects calcium dynamics in mice.

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

This study identifies METTL3's role in promoting homologous recombination repair and modulating chemotherapeutic response in breast cancer cells by regulating the EGF/RAD51 axis through m6A modification.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

This study shows TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy through Ca2+/CaMKII-mediated NFκB-NLRP3 activation, suggesting TRPV4 as a therapeutic target.

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

This study simulates reentrant arrhythmias in ischemic hearts with multiple electrophysiological remodelling stages, showing that spatial heterogeneity of refractory periods and excitation threshold differences drive reentry depending on border orientation relative to wavefronts.

The paper analyzes immune responses to malaria vaccination and finds that excessive early inflammation correlates with impaired immunity.

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

This study identifies pheromone receptors in Cnaphalocrocis medinalis that enable it to detect conspecific and heterospecific pheromones, aiding in avoiding competition in rice fields.

This study shows iminosugar glucosidase inhibitors suppress SARS-CoV-2 replication in tissue culture and enhance Remdesivir's effect.

This study identifies the enzymes responsible for biosynthesizing the N-hydroxytriazene pharmacophore in triacsins, revealing two ATP-dependent enzymes involved in consecutive N-N bond formation.

This study identifies auranofin resistance mechanisms in Toxoplasma gondii, showing reduced ROS accumulation without targeting thioredoxin reductase.

The paper develops a method to shrink-wrap corneal endothelial cells in extracellular matrix for improved engraftment, increasing cell density in the cornea.