Y. Hu

This study shows SMAD4 and TGFβ regulate gene expression in opposite ways to determine whether antiviral CD8 T cells become circulating or tissue-resident memory cells.

This study shows that quetiapine exposure increases antibiotic resistance in E. coli by inducing marR mutations and altering gene expression.

This study develops a 3D in vitro model of the device-tissue interface to show that antioxidant ceria nanoparticles reduce oxidative stress and neuroinflammation.

This study shows brilacidin has broad-spectrum antiviral activity against multiple human coronaviruses by targeting both the virus and host cell heparan sulfate proteoglycans.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study shows that GH3 amido synthetases conjugate auxin, and their deletion causes developmental defects in Arabidopsis roots and flowers.

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

This study identifies ELMOD1 and ELMOD3 as regulators of ciliogenesis and ciliary protein traffic, with phenotypes similar to ELMOD2 deletion but distinct in their effects on Golgi-ciliary transport.

This study compares the metabolic capabilities of gut symbionts in turtle ant larvae and adults, revealing functional overlap despite taxonomic divergence.

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

The paper identifies GPR87 as a novel marker for KRT5+ basal cells in IPF distal bronchioles and honeycomb cysts using single-cell RNA sequencing.

This study identifies Vinigrol as a broad-spectrum anti-cancer agent that activates the PERK/eIF2 arm of the UPR via ATF4/DDIT3 to induce breast cancer cell death.

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

This study shows that daily administration of LuCI, an oral gut coating agent, leads to weight loss and improved insulin sensitivity in a rat model of diet-induced obesity.

This study examines immune cell profiles in COVID-19 survivors with and without pulmonary sequelae one year post-discharge, identifying immune imbalances linked to residual lung damage.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

This study links genomic changes like WGD and gene duplication to phenotypic innovation and diversification in gymnosperms, showing ecological factors also drive diversification after angiosperms.

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

This study shows that elaborated feedback during instructor-learner interactions enhances learning transfer and is associated with neural synchronization in frontoparietal regions.

This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.