Y. Li

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

This study shows that the middle-aged thymic environment impairs central tolerance by reducing mTECs and antigen-presenting cells, leading to less efficient negative selection and Treg induction.

This paper develops two new strategies for constructing large variant DMS libraries in mammalian cells using piggyBac-mediated genomic integration and in-vitro ligation.

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

This paper develops bright fluorophores and uses heavy water to improve fluorescence imaging of deep-buried hollow organs, achieving better visualization and diagnosis.

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

The study examines diet and gut microbiome differences in three isolated Grauer's gorilla populations, finding population-specific profiles and co-variation between diet and microbiome.

This study shows that Akkermansia muciniphila induces chronic extramedullary hematopoiesis through cooperation between IL-1R and TLR signals in a mouse model.

The paper investigates how mutations in TM4 and TM6 helices of TMC1 affect mechanical gating of auditory transduction channels in hair cells.

The paper identifies and deletes 19 Myb genes in Magnaporthe oryzae, finds most are expressed during infection, and identifies co-regulated groups with potential roles in pathogenicity.

The paper withdraws a manuscript due to lack of required review and approval process.

The paper redescribes Conicula striata as a stem medusozoan with features of both anthozoans and medusozoans, suggesting an anemone-like ancestor for medusozoan cnidarians.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This paper describes an accelerated manufacturing process for adenovirus-vectored vaccines, enabling large-scale supply within 100 days of pathogen identification.

The paper identifies POPDC1 as a novel scaffold for AC9 that regulates heart rate by interacting with TREK-1 in an isoproterenol-dependent manner.

This study identifies MAIT cell heterogeneity in mice and humans through single-cell RNA sequencing and metabolic analysis, revealing distinct transcriptomes and metabolic states in different tissues and species.

This study maps 3D genome reorganization during skeletal muscle stem cell activation, proliferation, and aging using Hi-C, revealing how chromatin architecture influences gene expression and lineage progression.

This paper introduces self-confocal NIR-II fluorescence microscopy systems for in vivo imaging, improving adjustability and enabling cerebrovascular and hepatic imaging.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

This study investigates the biogenesis of propanediol-utilization metabolosomes in bacteria, revealing both 'Shell first' and 'Cargo first' assembly pathways.

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

The paper shows that reduced rDNA stability in yeast leads to rRNA-binding protein aggregation, linking chromatin instability to proteostasis loss during aging.

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

The paper identifies EEG spectral biomarkers of long-term memory retrieval by comparing immediate and delayed recall conditions.

The paper examines stomatal trait variation across forests, finding that stomatal conductance (g) and area fraction (f) show different patterns of variance and skewness, with implications for ecosystem productivity.