Y. Sun

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

This study analyzes Transcribed Ultra Conserved Regions (TUCRs) in gliomas, identifying uc.110 as a tumor enhancer that promotes malignancy via the WNT pathway.

This study shows losartan improves chemo-immunotherapy effectiveness in ovarian cancer by altering the tumor microenvironment and reducing IGF-1 signaling in cancer cells.

This study identifies STUB1 as a tumor suppressor in ccRCC by promoting YTHDF1 degradation, with low STUB1 expression linked to poor patient outcomes.

This paper introduces a 3D-printed microfluidic platform for modular metabolic engineering, demonstrating its ability to support xylose consumption and CO2 fixation in yeast.

This paper characterizes 5Me3F4AP, a novel K+ channel blocker with improved physicochemical properties and stability compared to existing PET tracers for demyelinated lesion imaging.

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

This study identifies a Sorcin-STAT3-Serpin E1/CCL5 signaling axis that drives pancreatic cancer-associated new-onset diabetes by impairing beta-cells and elevating serpin E1 levels in peripheral blood.

This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.

This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

This study compares carbon cycle metrics across tropical forests in West Africa and Amazonia, finding higher productivity and lower efficiency in West African forests.

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

This study shows that phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures with different neurotoxicity and propagation properties.

This study shows that Acvr1b loss in combination with Kras mutation promotes precancerous lesions from both acinar and ductal cells in the pancreas, but the IPMN-like phenotype differs when mutations occur in all cells.

This study determines the structure of the CD93-IGFBP7 complex and shows its role in endothelial cell angiogenesis and tumor microenvironment.

This study detects and characterizes novel luchacoviruses in meso-carnivores in the northeastern US, revealing genetic distinctions from known rodent and lagomorph isolates.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This paper determines the structure of a peptide-centric Chimeric Antigen Receptor (PC-CAR) complex and identifies structural principles for antigen recognition across multiple HLA allotypes.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

This study identifies PRMT5-mediated methylation of Lsm11 and SmE in U7 snRNP, suggesting a role in its unique assembly.

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

This paper develops a multiscale model for ion transport in multicellular tissues and applies it to study smooth muscle cell activation under various stimuli, showing the importance of gap junctions and extracellular potassium.

This paper introduces a fluorescent probe, PCV-1, and an analytical assay called organelle ratiometric probing (ORP) to quantify cell viability at the single-cell level using super-resolution microscopy.

This study investigates chromosome loss in CRISPR-Cas9-engineered T cells and shows a modified manufacturing process reduces it while preserving editing efficacy.

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.