Y. Wang

This study identifies two MAPK pathways that inhibit APC/C activity during mitotic arrest in fission yeast, clarifying their role in spindle checkpoint activation and chromosome segregation.

This study computationally examines the diodicity of the Tesla valve for active swimmers without fluid flow, finding higher resistance in the reverse direction.

This paper introduces a machine learning method to estimate species presence probability from presence-background data, showing improved performance over existing methods.

This study introduces a new remote sensing index for urban ecological monitoring by integrating air quality data with existing ecological factors, showing improved assessment in Beijing.

This study shows that TSS inhibits the TLR3 pathway, reducing CVB3 infection severity in mice and cell cultures.

The paper identifies the CD58:CD2 axis as co-regulated with PD-L1 via CMTM6 and shows its role in anti-tumor immunity, proposing therapeutic strategies to enhance immunotherapy.

This study shows that AtEH1 and AtEH2 subunits of the TPC complex drive biomolecular condensation to facilitate clathrin-mediated endocytosis in plants, with their disordered regions regulating condensate properties and endocytosis dynamics.

The paper identifies Cyr1 interacting partners in Candida albicans using SILAC-based proteomics, revealing potential roles for cell wall proteins in cAMP signaling.

This paper designs and tests bispecific nanorings targeting B7-H3 and CD3 to enhance T-cell responses against medulloblastoma, showing improved tumor infiltration and reduced toxicity.

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

This paper shows a chemical molecule enhances the differentiation of biliary duct organoids into insulin-secreting cells, improving glucose sensitivity in diabetic mice.

The paper shows that WDR82-mediated H3K4me3 promotes tumor proliferation and affects therapeutic response in pediatric high-grade gliomas.

This study shows SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion by altering its structure and function.

This study shows that tyrosine phosphorylation modulates TRPV2's chemical and thermal sensitivity in macrophages through JAK1 and PTPN1.

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.

The paper develops an islet-on-a-chip device to measure glucose-stimulated respiration and Ca2+ activity in individual islets, showing OxPhos is substrate-limited by NADH rather than ADP and independent of Ca2+.

This paper introduces a biomimetic trogocytosis platform using farnesylated chemically self-assembled nanorings to enable directional cargo transfer between cells.

This study shows that modifying CAR activation motifs improves anti-tumor efficacy in solid tumors despite reduced in vitro cytotoxicity.

This study identifies Jeholornis as the earliest known frugivorous bird, providing evidence for bird-mediated seed dispersal during the Early Cretaceous.

This paper develops a bispecific antibody tethered to keratinocytes to locally block IFNγ in vitiligo, showing improved skin retention and reduced systemic effects.

The paper identifies ITPRIPL1 as a novel immune checkpoint that inhibits T cell activation by interacting with CD3ε, suggesting it as a therapeutic target for PD-1/PD-L1 negative tumors.

The paper identifies ORA47 as a transcriptional regulator involved in the general stress response by interacting with the RSRE motif and functioning with CAMTA3 and JAZ1.

The paper identifies deleterious mutations in human influenza H3N2 neuraminidase and reveals epistatic networks shaping its evolution.

This study shows that thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination, cell death, and Type 1 interferon expression in CD8+ T cells.

This study shows that methionine metabolism regulates EBV epigenetic states and latency in B-cells, with methionine restriction impairing viral gene silencing and immune evasion.

This study compares the biological effects of orthovoltage X-rays and 137Cs γ-rays in mouse models, finding that lower-energy X-rays cause more severe hematopoietic and intestinal injury at equivalent physical doses.

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

The paper analyzes histone modifications and chromatin accessibility in Phytophthora infestans to reveal distinct genomic compartments and their association with virulence factor genes.