Y. Wang

ID-Seg improves segmentation accuracy of limbic structures in infant MRI scans, showing strong brain-behavior associations in a medium-size dataset.

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

This study shows that the balance between saturated and unsaturated fatty acids, regulated by SCD, affects ovarian cancer cell survival and tumor progression, with UFAs protecting against ER stress-induced apoptosis.

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

The paper develops a microfluidic chip for LAMP-based multiplex detection of three bacterial pathogens and reports LOD values for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

This study shows that intersegment epistasis between hemagglutinin and neuraminidase constrains the evolutionary potential of the influenza A virus hemagglutinin gene.

This study reveals a bimodal pattern of Piezo1-mediated intracellular calcium and FAK signaling, dependent on the degree of Piezo1 activation.

The paper identifies a public antibody response that cross-neutralizes all SARS-CoV-2 variants, including Omicron, by analyzing published data on germline gene combinations and molecular features.

The paper identifies a rare SARS-CoV-2 mutation in ORF1ab that may trigger autoimmune T cell responses via epitope mimicry, potentially linked to hepatitis of unknown cause.

This study identifies distinct gut microbiome signatures in adult atopic dermatitis patients compared to healthy individuals in southern China.

The paper examines intraspecies diversity and evolutionary patterns of microbial populations in deep sea cold seep sediments, finding depth-dependent diversification and purifying selection on key metabolic genes.

The paper investigates HIV-1 spike protein dynamics using cryo-EM and simulations, showing how tilting exposes the MPER to antibody attack and alters membrane fusion.

The paper identifies a new endolysosome process, LEA, where autophagosomes are engulfed by extending arms (LF) without fusion, and describes the molecular markers of engulfed autophagosomes.

The paper develops a microfluidic droplet array for high-throughput screening of lipid-producing microalgae, enabling real-time monitoring and identification of individual cells under different conditions.

The paper describes a semi-automated protocol to quantify and characterize 3D vascular images in mouse tissues, achieving 80% sensitivity and 90% specificity in automated segmentation.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

This study determines the structure of NF-κB p52 homodimer-DNA complexes and shows how DNA conformation and binding kinetics influence transcriptional activation.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper identifies a truncated suPAR fragment, D2D3, that causes kidney disease and autoimmune diabetes by impairing pancreatic beta-cell function and kidney health.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This study uses 3D single-molecule tracking to identify distinct cytosolic complexes of injectisome proteins in live Yersinia enterocolitica cells, revealing their interactions and abundance.

This paper models the fluke-and-glide gait of bottlenose dolphins and finds it reduces metabolic and mechanical costs of transport compared to continuous fluking.

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

This study identifies myeloid HIF1A as a cardio-protective factor during ischemia and reperfusion, mediated by netrin-1 induction in neutrophils.

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

This study investigates microbiota dysbiosis and liver metabolomic changes in rats during brain death, finding dysbiosis but no changes in microbial metabolites and significant liver metabolic deterioration.

The paper identifies HSD3B1 as an enzyme in human placenta that converts oxysterols into 3-oxo-4-ene derivatives, which are found in umbilical cord and maternal plasma.

This study validates and invalidates SARS-CoV-2 main protease inhibitors using cell-based and cell-free assays, showing most repurposed drugs are not specific to Mpro.