Y. Wang

This paper presents crystal structures of four plant AAAD paralogs, revealing structural features and mutations that underlie divergent substrate selectivity and convergent aldehyde synthase activity evolution.

The paper identifies 19 new BCCR proteins from cryptophyte algae, revealing distinct conductance mechanisms and rapid desensitization in two subfamilies through electrophysiology and spectroscopy.

This study investigates how TSG-6 affects BMP-4/Smad signaling and odonto/osteogenic differentiation of DPSCs in an inflammatory environment.

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

This study examines cross-reactive antibody responses between SARS-CoV-2 and SARS-CoV, finding common binding but rare neutralization, suggesting non-neutralizing antibodies target conserved epitopes.

This study investigates how menthol in e-cigarettes affects human bronchial epithelium using three in vitro models, finding adverse effects including oxidative stress and inflammation.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

This study shows microampere electric currents cause bacterial membrane damage and two-way leakage within 30 minutes.

The paper derives a structural model of the TIM9{middle dot}10{middle dot}12 complex using NMR, X-ray scattering, and MD simulations, revealing dynamic subunit exchange and conformational changes.

The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

This study shows that reduced α2-6 sialylation in synovial fibroblasts contributes to a pro-inflammatory phenotype in RA by altering glycosylation pathways.

The paper identifies 291 protein complexes and 24,092 PPIs in Synechocystis sp. PCC 6803, revealing functional roles of previously uncharacterized proteins and their interactions across biological processes.

This study evaluates an SIV-based IDLV vaccine expressing sequential CH505 Envs in rhesus macaques, showing improved antibody responses and virus control but no broadly neutralizing antibodies.

The paper assesses the risk of desert locust invasion into China by analyzing climate data and wind patterns, concluding that the risk is very low.

This study shows that cytosolic Ca2+ modulates Golgi structure via PKC-mediated GRASP55 phosphorylation, independent of ER stress.

This study shows that ICOS overexpression in mice worsens liver inflammation and fibrosis in Schistosoma japonicum infection by increasing Tfh cell frequency and altering cytokine responses.

BR-activated BZR1 suppresses ACO1 activity and expression of ACO1 and ACS1a, reducing ethylene production during pear and apple fruit ripening.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

This paper shows epigenetic reprogramming of mesenchymal stem cells into CA-MSCs drives ovarian cancer metastasis through partial MET and WT1/EZH2-mediated mechanisms.

This study shows that Mitofusin 2 suppresses Rac activation to regulate neutrophil adhesive migration and actin cytoskeleton dynamics.

The paper investigates the role of pcyt-1 gene expression in pine wood nematode departure from its beetle vector, finding that up-regulation of pcyt-1 promotes lipid degradation and motility necessary for departure.

This study identifies ALK1 as a target of miR-31-5p in CD, showing that decreased ALK1 disrupts epithelial barrier integrity and correlates with poor clinical outcomes.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

This study shows that Drosophila larval epidermal cells do not age during the larval stage but exhibit aging signs if they persist into the adult stage.

The paper develops a robust ChIP protocol that significantly improves enrichment fold in birch and Arabidopsis, and is applicable to both woody and herbaceous plants.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study investigates how silver ions inhibit bacterial motility by affecting flagellar motor function in E. coli, showing reduced swimming speed and altered tumbling behavior.