Y. Wang

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study shows suramin inhibits SARS-CoV-2 replication in cell cultures by targeting early replication steps, with potential for clinical evaluation.

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

This study shows that ACE2-overexpressed mesenchymal stem cells improve cardiac function and reduce fibrosis in a rat myocardial infarction model.

This study shows that Nelfinavir inhibits DDI2, blocking NFE2L1 proteolysis and enhancing the effectiveness of proteasome inhibitors in cancer treatment.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This study determines the structure of the mammalian PA28β-iCP immunoproteasome using cryo-EM, revealing a unique mechanism of proteasome activation distinct from constitutive proteasomes.

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

This study investigates abortion rates and risk factors in dairy cows and sheep in Ili, China, identifying Brucella melitensis as the main pathogen and highlighting management factors contributing to reproductive issues.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

The paper identifies and characterizes two new families of anion channelrhodopsins (ACRs), including RubyACRs with highly red-shifted absorption spectra, expanding optogenetic tools for neural inhibition.

The paper investigates the host range of SARS-CoV-2 and related coronaviruses and identifies an improved ACE2-Fc variant effective against both SARS-CoV-2 and SARS-CoV-1.

This study uses AI-aided molecular dynamics to analyze conformational flexibility in T4 lysozyme mutants, revealing how sequence changes affect loop stability and dynamics.

The paper shows that skin blisters heal by sacrificing developmental programs, with HF stem cell progeny repairing wounds without promoting hair follicle growth.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

This paper develops microbial strains for producing renewable fatty acid esters, achieving high yields and economic competitiveness in bioproduction.

This paper proposes a two-stage deep learning method for ECG denoising using U-net and DR-net models, showing improved performance over single-stage methods.

The paper develops a self-immobilizing NIR probe activated by SA-β-Gal for non-invasive imaging of senescence in mice.

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

This study classifies and analyzes the expression of heat shock proteins in wheat infected with powdery mildew and stripe rust, revealing structural diversity and differential expression patterns.

This study shows that KLF14 overexpression reduces infarct size and preserves cardiac function after myocardial infarction by protecting mitochondria and increasing PGC-1 levels.

The paper identifies a K+ sensing mechanism in plant roots that triggers ROS signals and activates K+ uptake transporters and Casparian strip maturation.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.