Y. Zhang

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

The paper shows C/EBPα binds RNA via novel domains, recruits to enhancer sites, and promotes Macrophage differentiation by regulating PU.1 expression.

This study examines how social mobility affects biological aging in older U.S. adults, finding that upward mobility is linked to slower aging but with racial disparities in educational mobility benefits.

This paper introduces HiLo microscopy for rapid, non-destructive lung adenocarcinoma pathology with high resolution and speed, comparable to gold-standard histology.

This study compares Exo1DA/DA mice with nuclease-dead EXO1 to Exo1-/- and Exo1+/+ mice to show EXO1 has both enzymatic and scaffolding roles in DNA repair, immune response, and tumor suppression.

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

This study shows that cigarette smoke triggers mitochondrial DNA release in COPD patients and animal models, linking it to inflammation and disease progression.

The paper identifies light-responsive genes regulated by PIF and shows that chromatin changes, specifically H3K9 acetylation, parallel rapid transcriptional responses to light.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

This study shows that loss of Nrf1, not Nrf2, causes lipid and ROS accumulation in hepatoma cells, which can be reduced by 2-bromopalmitate.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The paper reports the cryo-EM structure of human ALDP, revealing its conformation and potential lipid-binding site, which aids in understanding disease-causing mutations.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study develops a bottom-up nanofabrication strategy to control integrin ligand assembly, enabling tunable suppression of cancer cell migration through precise ligand density modulation.

This study identifies metabolic markers and pathways in pancreatic tumor-associated macrophages using multi-omic analysis and in vitro models.

This study identifies Lem8, a protease effector from Legionella pneumophila, which inhibits host cell motility by targeting Phldb2 via 14-3-3ζ-dependent activation.

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

The paper identifies two ubiquitin-activating systems in plants, showing that one E1 plays a major role in plant immunity by differentially charging ERAD-associated E2s for ER stress tolerance.

This study identifies the roles of three MAPKs in Trichoderma brevicrassum strain TC967's biocontrol against Rhizoctonia solani and shows that deleting Fus3- and Slt2-MAPK genes enhances disease control.

The paper constructs a global microbiome transition network showing microbiomes are closely connected despite habitat differences, with a scale-free structure and a roadmap of dispersal.

This study identifies key traits enabling Schrenkiella parvula to maintain growth and reproductive success under salt stress.

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

The paper solves the native structure of a human GBP coatomer that coats cytosolic bacteria and functions as an antimicrobial signaling platform.

This study identifies two E protein inhibitors for SARS-CoV-2 using structural modeling and virtual screening, including a compound in clinical trials.

The paper introduces a universal microfluidic method for studying bacterial biofilms, demonstrating insights into H2O2 resistance and resource retention mechanisms in E. coli and P. aeruginosa biofilms.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

This study shows that a protein-based RBD-C-tag vaccine candidate provides protection against multiple SARS-COV-2 variants in mice.

This paper identifies additional receptor binding sites on SARS-CoV and SARS-CoV-2 spike protein subunit 1 through peptide scanning and validates their ACE2 binding affinity.

The paper identifies ultrapotent antibodies from convalescent donors that neutralize SARS-CoV-2 variants and reduce escape mutant generation.