Y. Zhang

The paper uses CETSA MS to identify novel crosstalk between brassinosteroid and auxin signaling in Arabidopsis by analyzing the thermal and phospho-proteomes of the GSK3 inhibitor bikinin.

This study shows the ColR/S two-component system is conserved in Pseudomonas species and required for host association, but its regulon diverges between strains with different lifestyles.

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

This paper uses deep learning to segment 15 intracellular compartments from super-resolution images with one dye, achieving high accuracy and faster imaging.

The paper shows TRPV4 activates TMEM16F in trophoblasts, promoting cell fusion, and identifies this as a mechanism for syncytialization and disease-related fusion.

This paper identifies Rlm4 and Rlm7 as alleles of the Rlm9 resistance locus in Brassica napus, encoding WAKL proteins that confer resistance to Leptosphaeria maculans.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

This paper develops a vascular bundle detection model for Phyllostachys and finds consistent radial gradient patterns across 29 species.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

The paper derives stability criteria for microbial communities based on resource exchange and consumption dynamics, showing that stability depends on resource environment and interaction network structure.

This study reveals how PLN mutations reduce phosphorylation by altering conformation and PKA interactions, contributing to DCM.

The paper investigates age-dependent H3K9 acetylation changes in rice flag leaf senescence, finding increased H3K9ac levels correlate with gene expression and identify regulatory networks.

The paper uses optogenetics to manipulate cGMP levels in megakaryocytes and identifies PDE5 as the main enzyme regulating cGMP.

This paper introduces TRUST, a fast 3D imaging method for centimeter-scale specimens, enabling multicolor subcellular imaging without extensive sample preparation.

The paper identifies secretory cells as the main source of pIgR in airways and shows reduced pIgR protein expression, not cell numbers, contributes to SIgA loss in COPD.

This study identifies RPRM as a negative regulator of ATM levels through phosphorylation by CDK4/6, enhancing cellular sensitivity to genotoxic agents and radiation.

This study investigates the molecular basis of reactive sulfur species specificity in CstR proteins, revealing structural and chemical asymmetry in their reactivity.

This paper introduces a new cryo-EM support film using HFBI protein 2D crystals to improve protein structure resolution by reducing preferred orientation and denaturation during vitrification.

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

The paper analyzes the transcriptome of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine to understand immune response mechanisms and vaccine effectiveness.

This study shows that parental environmental effects are common and strong in Arabidopsis thaliana but are genotype-dependent and unpredictable across different stress treatments.

This paper identifies a non-canonical, methyltransferase-independent mechanism by which EZH2 promotes melanoma progression through interactions with IMPDH2 and GTP synthesis.

This study uses scRNA-seq to define immune cell communities in CSF of MS and other neuroinflammatory diseases, identifying changes in cell types and potential therapeutic targets.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

The study finds that stomatal conductance model parameters m and g1 are consistent across diverse maize genotypes under varying water supplies, suggesting flexibility in water use efficiency mechanisms.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

The paper isolates and characterizes two novel photosystem I supercomplexes from cyanobacteria, revealing the structure of the PSI octamer at near-atomic resolution.

This study investigates the mechanism by which TMPyP4 induces unfolding of RNA G-quadruplexes using simulations and experiments, revealing a two-state interaction mechanism.