Y. Zhang

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.

This study identifies a compound that inhibits both wild-type and TMP-resistant variants of E. coli DHFR, delaying resistance development through efflux pump duplication.

This paper introduces spatially expandable fiber-based probes for deep brain interface, enabling three-dimensional recording and stimulation of neural activity with high resolution and minimal tissue damage.

The paper develops a triple functional sensing chip that detects L. monocytogenes by analyzing three biomarkers, reducing false positives and detection time to 90 minutes.

This study analyzes the roles of two Mg2+ ions in DNA polymerase specificity and catalysis using kinetic analysis and molecular dynamics simulations.

This study reports the first systematic analysis of aphid and parasitoid wasp species composition and dynamics in maize fields of Jilin Province, China, over two years.

The paper investigates how pore constrictions in pit membranes relate to embolism resistance in angiosperm xylem and finds that pit membrane thickness strongly influences constriction size and embolism resistance.

The paper identifies 997 MYB genes in wheat, focusing on 445 R2R3-MYBs, and analyzes their expression patterns across 61 tissues and time points, revealing subgroup conservation and duplication mechanisms.

The paper identifies a bacterial toxin immunity gene acquired by gut fungi through horizontal gene transfer, providing evidence of its role in fungal survival in the gut microbiome.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study identifies KIM1 as a potential receptor for SARS-CoV-2 in the kidney, showing it binds RBD with similar affinity to ACE2 and facilitates viral entry.

Increased light availability enhances stress resistance in Halimeda opuntia by the accumulation of soluble organic molecules and enzyme-driven activities to alleviate ocean acidification stress.

This study shows that manipulating the ISI can transform the N170 into an RP, suggesting that morphology-based classification of ERP components may not be reliable when using forward masks.

This paper identifies USP19 as a modulator of Nrf1 stability and activity by preventing its ubiquitination and degradation, showing its role in tumor growth regulation.

This study develops CRISPR/Cas12a for genome editing and transcriptional repression in R. capsulatus, achieving high editing and repression efficiencies.

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

This study identifies 129 loci associated with 27 yield-related traits in tomato, explaining 8.8% of phenotypic variance, and highlights a candidate gene involved in leaf stomata formation and drought resistance.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

The paper introduces a framework to quantify microbial community assembly mechanisms in grassland soils under warming, finding homogeneous selection and drift dominate, with warming altering their relative contributions.

This study evaluates phage-based FMDV vaccines through meta-analysis and experiment, showing protective effects and immune responses in mice.

This study identifies phosphorylated residues in RBM20, showing their role in splicing control and protein shuttling, and links their mutation to cardiac dysfunction.