Y. Zhang

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

This study investigates how UV irradiation affects transcription factor DNA-binding specificity using UV-Bind, finding reduced specificity and unexpected increased binding at non-consensus sites.

This study identifies the functional roles and evolutionary divergence of four LFY homologues in woodland strawberry, showing that only FveLFYa is critical for floral patterning.

The paper reports cryo-EM structures of cyanobacterial transcription initiation complexes and identifies an SI3-{sigma} arch that stabilizes the RNAP-promoter DNA open complex, essential for transcription initiation.

The paper analyzes memory effects in repetitive protein-protein interactions using experimental techniques and models, finding short- and intermediate-term memory in TCR-pMHC interactions.

The paper shows HY5 regulates GLK transcription factors to control chloroplast development and hypocotyl elongation during light-induced seedling development in Arabidopsis.

This study identifies the N-terminal extension of Arabidopsis AGO1 as essential for miRNA activity, showing its role in miRNA loading and trans-acting siRNA biogenesis.

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

The paper develops a deep learning model that classifies metastatic tumors from primary tumors using mutational signatures from genomic data.

The paper externally validates fall prediction models using trunk accelerometry and questionnaires, finding limited improvement in accuracy despite recalibration and parameter optimization.

This study investigates the distinct roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII, revealing that MCFD2 binds cargo and LMAN1 acts as a shuttling carrier.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

This study reevaluates Piezo1's role as a gut RNA sensor and finds that fecal ssRNA does not activate Piezo1, supporting its function in mechanosensation.

This study identifies CURLY LEAF (CLF) as a key regulator of apoplast water status in Arabidopsis by modulating ABA signaling and stomatal closure.

The paper develops a formula to convert GDS-15 scores to GDS-30 scores using a dataset of older adults, finding that multiplying by 2 is inaccurate and providing an alternative formula with higher explained variance.

This study estimates heritability of physiological traits in Porites astreoides across life stages, finding high genetic influence on larval chlorophyll a concentration and variable heritability across traits and stages.

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

The paper shows MATR3 and antisense LINE1 RNAs form a meshwork that organizes chromatin, and their disruption causes chromatin reorganization.

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

This study shows that far-red light enhances maize's response to herbivore-induced volatiles by altering photosynthesis and phytochrome B signaling.

This study evaluates the in vivo safety and immunoactivity of Jurona virus in hepatocellular carcinoma using proteogenomic analysis, showing tumor regression and enhanced immune responses.

This study shows that loss of ANT1 increases fibrosis and epithelial cell senescence in IPF by causing mitochondrial dysfunction.

The paper investigates the dynamics and function of Munc18-mediated SNARE template complexes using optical tweezers, revealing a dynamic conformational transition that facilitates specific SNAP-25 binding.

The paper characterizes a plastid glycolytic-gluconeogenesis pathway in diatoms, showing its functional roles and environmental regulation.

The paper uses locus-specific proteomics to identify proteins associated with the V region chromatin in SHM and validates their function using a Dot1L inhibitor.

The paper predicts MPXV T cell epitopes using VACV epitope data and identifies immunodominant targets to design peptide pools for detecting cross-reactive T cells in vaccinated individuals.

This study identifies FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer, showing it induces cell cycle arrest, apoptosis, and synthetic lethality through chromatin accessibility reduction and DNA repair impairment.

This study compares root growth responses of the halophyte Schrenkiella parvula and Arabidopsis thaliana under salt stress, identifying gene regulatory differences and physiological adaptations that enable salt tolerance.

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.