Y. Zhang

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

This study identifies Chlamydia trachomatis proteins that target mitochondria and alter their protein composition during infection, affecting apoptosis and metabolism.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study shows cAMP competitively inhibits periplasmic phosphatases in H. influenzae, linking nucleotide utilization to competence development.

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

This paper introduces PRIME-PAINT, a method for multiplexed fluorescence nanoscopy with millimeter-scale field-of-view and high resolution, demonstrating its use on biological samples.

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.

This study investigates how CAMSAP proteins and CDK5RAP2 regulate microtubule release from γ-TuRC, revealing their roles in microtubule nucleation and stabilization.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study identifies TMEM65's role in mitochondrial calcium regulation, showing its loss causes mitochondrial disease and suggesting therapeutic targeting of mitochondrial calcium as a potential treatment.

The paper demonstrates that swim bladder resonance enhances hearing in crucian carp through auditory evoked potentials, Micro-CT, and numerical simulations.

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

This study investigates Cu-dependent antioxidant defenses in mitochondria and cytosol using redox sensors and proteomics, revealing distinct redox responses and protein changes in each compartment.

This paper describes a method to generate human atrial-like cardiomyocytes from induced pluripotent stem cells that respond to adrenoceptor agonists.

This study examines two anoxic foraminifera, revealing distinct mitochondrial and peroxisomal metabolic strategies that support their survival in low-oxygen environments.

This study identifies βγ-CAT as a pore-forming protein that enables cells to scavenge extracellular proteins under starvation by promoting nutrient uptake and survival.

This paper shows that recombination is suppressed around the mating-type locus in Schizothecium tetrasporum, a fungus in the Sordariales order, leading to self-fertile dikaryotic spores through stepwise recombination suppression.

This study identifies H2BFWT's role in spermatogenesis by showing its impact on nucleosome stability and gene expression through structural and functional analyses.

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

This study identifies how melanoma cells use pericyte:endothelial cell signaling during brain invasion, showing that Sox9hi mesenchymal cells use Snail1-dependent mechanisms while Sox10hi cells form clusters.

This study investigates how two Keap1 isoforms, α and β, differentially inhibit Nrf2 and influence malignant behaviors in hepatocellular carcinoma.

This study reports cryo-EM structures of Omicron subvariant S proteins, revealing conformational differences linked to transmissibility and immune evasion.