Y. Zheng

This paper introduces a light-driven molecular motor system to apply forces to cellular receptors, demonstrating its ability to manipulate cell adhesion and activation.

This study identifies BRD9-containing non-canonical BAF complex as a regulator of Foxp3 in Tregs using a genome-wide CRISPR screen.

This paper introduces an APEX2-based method to map proteins, RNA, and DNA associated with the nuclear lamina, revealing new insights into its regulatory roles and dynamic interactions.

This study identifies differences in the oral microbiome between NPC patients and controls, highlighting a pair of co-excluding Granulicatella adiacens variants associated with cancer risk.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

The paper identifies type-1 IFN-primed monocytes as key drivers of fibrosis in IPF, showing their increased levels, altered phenotype, and potential as therapeutic targets.

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

This study links cellular virological stages in chronic hepatitis B to liver fibrosis progression through spatial and functional analysis of viral and host gene expression.

This paper identifies a novel perinuclear microtubule-organizing center in Drosophila fat body cells that controls nuclear positioning and basement membrane secretion through specific protein interactions and MT assembly mechanisms.

This study uses single-cell RNA sequencing to identify an endosymbiotic cell type in a soft coral and reveals its lineage dynamics during algal uptake and maintenance.

Deep-Channel uses deep neural networks to automatically detect single-molecule events in patch-clamp data more accurately and faster than traditional methods.

This study shows obesity increases TH2 immunopathology by disrupting PPARγ in T cells, and TZDs can protect against this effect in obese mice.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

The paper investigates the role of xa5 in BLS resistance by analyzing transcriptome changes in Xa5-RNAi rice lines compared to wild-type, finding enhanced cell death gene responses.

This study shows that miR-15a mimic, especially modified with 5-FU, reduces PDAC cell proliferation and tumor growth, suggesting its therapeutic potential and prognostic value.

The paper investigates the role of CSI1 and microtubules in cell wall architecture during acid growth in Arabidopsis hypocotyls, finding that CSI1-dependent crossed-polylamellate walls are essential for auxin-induced cell elongation.

The paper uses single-cell sequencing to identify non-genetic heterogeneity in serous ovarian cancer by analyzing normal fallopian tube epithelial cells and their subtype signatures.

This study identifies ANP32A and ANP32B as essential host factors that facilitate HIV-1 unspliced RNA export via the Rev-CRM1 pathway.

This study characterizes and repurposes the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis to create an efficient genome engineering toolkit with 100% efficiency in various genetic modifications.

This study identifies and analyzes genes involved in ABA production, catabolism, and transport in peanut leaves under drought stress, showing their coordinated regulation of ABA homeostasis.

This study identifies and validates a novel QTL on chromosome 6HL in barley that confers resistance to Fusarium crown rot, explaining 29.1% of phenotypic variance.

This study identifies two bile acid metabolites that regulate Th17 and Treg cell differentiation through distinct mechanisms, affecting immune balance in mice.

This study shows lamin-B1 in thymic epithelial cells is reduced with aging due to inflammation, leading to thymus degeneration and impaired function.

The paper identifies a HIF-pathway-responsive cryptic promoter driving POU5F1 expression in RCC, linked to poor patient outcomes.

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.

The paper examines the correlation between deletion rates and dN/dS ratios in mammalian protein sequences and finds significant positive correlations not explained by alignment errors or mutation rates.

This study uses simulations to show that small-RNA-mediated repression of transposable elements evolves rapidly in response to genomic invasion and fitness costs.