Z. Li

This study shows tobramycin reduces lung inflammation in pwCF by increasing 5' tRNA-fMet halves that suppress IL-8 and neutrophil recruitment via AGO2 gene silencing.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This paper introduces a modular multilevel TMS device capable of generating a wide range of pulse shapes and widths, enabling quieter TMS through shorter pulses.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study identifies Cln1 as a regulator of G2 arrest and titan cell formation in Cryptococcus neoformans under stress conditions.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

This study identifies a pyroptosis-related molecular classification and prognostic signature for glioma using integrative analysis of genomic and clinical data.

This study investigates neophobia in 10 corvid species, finding species differences and socio-ecological influences on novelty responses across 241 subjects in 10 labs.

This study reports a pan-drug-resistant Klebsiella pneumoniae isolate carrying NDM-5 and MCR-8.2 genes, along with chromosomal resistance mechanisms to colistin and tigecycline.

This study identifies NGF-p75 signaling as critical for coordinating skeletal cell migration during bone repair by affecting osteogenic precursor migration and bone healing.

This paper introduces two genetically encoded fluorescent biosensors to monitor UDP-GlcNAc and related nucleotides in live cells, demonstrating their use in studying metabolic and pharmacological perturbations.

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

This study investigates underwater CAM in Isoetes taiwanensis using genome and RNA-seq data, identifying key differences in carboxylation and circadian control compared to terrestrial CAM.

This study identifies two types of scales in an Early Cretaceous bird fossil, suggesting all four modern bird scale types existed by that time.

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

High copper availability represses SPL7, releasing its suppression on key ABA biosynthetic genes and leading to increased ABA accumulation that inhibits growth but enhances drought tolerance.

The paper shows EP400NL forms a chromatin remodeling complex that activates PD-L1 gene expression via cMyc, suggesting it as a target for cancer immunotherapy.

This paper identifies aCPSF1 and terminator U-tract synergy in archaeal transcription termination, showing their roles in determining termination efficiency through KH domain binding and nuclease activity.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This paper introduces an MRI-based data fusion method for simulating aortic haemodynamics, achieving accurate and efficient patient-specific compliant simulations without CT data.

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

This study examines genome size evolution in Trichoptera, finding that repetitive element expansions, especially transposable elements, drive large genome sizes and are linked to ecological diversity.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

The paper provides evidence that the death domain of the p75 neurotrophin receptor exists in equilibrium between monomeric and dimeric forms in solution.

RNA-CLAMP enables photo-activated control of CRISPR-Cas9 gene editing by clamping and photo-cleaving sgRNA stem loops to regulate activity.

The paper investigates an IR-dependent flow-driving mechanism in blood vessels that can propel blood circulation independently of the heart, showing increased flow with IR energy and reduced flow without it.

The paper shows that body size heritability remains constant in sticklebacks across ontogeny, but different genetic loci contribute to this heritability at different developmental stages.

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.