Z. Li

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

This paper identifies a novel non-covalent inhibitor of SARS-CoV-2 main protease through high throughput virtual screening, validated by biochemical assays, X-ray crystallography, and molecular dynamics simulations.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

This study shows bacterial effectors can move between plant cells via plasmodesmata, with movement dependent on molecular weight and regulated by PD proteins and flg22 peptide.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

This study reveals how silkworms use metal ions and pH gradients to drive the self-assembly of silk fibroin nanofibrils into herringbone-like structures for fiber spinning.

This study shows that optimal brassinosteroid (BR) signaling is necessary for proper cell wall orientation in the Arabidopsis root meristem, with defects linked to altered cortical division zone localization.

This study estimates quantitative genetic parameters in sticklebacks using IBD sharing, finding that low relatedness variance impairs estimation but half-sib designs allow accurate heritability and additive variance assessment.

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

The paper identifies two plasmodesmata-located proteins that regulate plasmodesmata at distinct cell-cell interfaces, highlighting their role in differential intercellular communication.

The paper identifies a Ca2+-dependent pathway that triggers phosphatidylserine exposure on necrotic neurons in C. elegans.

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

This paper identifies interfacial compatibility conflict as the cause of poor dentin bonding durability and shows that hydrophobizing the demineralized dentin matrix enhances adhesive infiltration and bonding strength.

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.

The paper presents the cryo-EM structure of the human Nav1.5-E1784K variant and identifies a mutational hotspot in fast inactivation segments linked to LQT3.

This study compares three qRT-PCR assays for SARS-CoV-2 detection, finding that CCDC and IPBCAMS N gene assays outperformed WHO assays, while IPBCAMS ORF 1b assay had higher detection rates than others.

The paper identifies IRP as a DAMP in rice immunity, showing it activates MAPKs and OsWRKYs to amplify chitin signaling.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

This study uses single-cell RNA sequencing to analyze chicken peripheral blood lymphocytes infected with ALV-J, identifying T cell subsets and their molecular responses to infection.

This study shows that Neuropilin-1 facilitates SARS-CoV-2 infection by promoting the separation of Spike protein domains S1 and S2 through molecular dynamics simulations.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study investigates the neuroprotective role of CTRP1 in TBI rats, finding it reduces inflammation and modulates autophagy through mTOR activation.

The paper identifies transcription factors involved in COVID-19 cytokine release syndrome and evaluates repurposed drugs to inhibit cytokine production.

This study shows ESR1 mutant breast cancers exhibit basal cytokeratin expression and immune activation, linked to chromatin reprogramming and paracrine signaling.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This study determines the cryo-EM structures of Cas12f to elucidate its dimerization-dependent mechanism for DNA cleavage and substrate recognition.