Z. Wang

The paper analyzes microRNA dynamics during pollen development, showing a shift from regulating developmental genes to controlling transposable elements in mature pollen.

Loss of Polymerase IV function in Capsella rubella causes microspore arrest, revealing an important functional role of Polymerase IV during pollen development.

This study develops SSR markers linked to seed storability traits in maize by mapping QTL in two populations and identifies four markers with high selection efficiency.

This study shows that TLR2 signaling reduces S. uberis infection severity by promoting mitochondrial reactive oxygen species production in mammary epithelial cells.

The paper identifies CbuSPL9 and its interacting protein CbuHMGA in Catalpa bungei, showing they form a heterodimer and may regulate flowering development, not transition.

The paper investigates how single chromosome gains can either suppress or promote metastasis in cancer, showing that specific aneuploidies are linked to distinct clinical outcomes.

This paper identifies model organisms for studying ALK and LTK proto-oncogenes by analyzing their evolutionary history and ligand homology across species.

This paper develops a Saak transform-based machine learning framework for efficient segmentation and quantification of cardiac trabeculation in light-sheet images after chemotherapy.

The paper shows a correlation between the evolutionary rates of cockroach mitochondrial genomes and their endosymbiont genomes.

This study evaluates how different nitrogen fertilizer rates affect tuber yield and processing quality of two potato cultivars, finding optimal rates for high yield and quality.

This paper introduces a machine learning method to design human IgG antibodies with superior target affinity and specificity, using high-throughput data without requiring target structural information.

The paper identifies immune dysregulations in atherosclerotic plaques linked to ischemic cerebrovascular events using single-cell analyses of T cells and macrophages.

This paper develops a syngeneic mouse model of tobacco-associated HNSCC that shows high response rates to anti-CTLA-4 therapy.

This study evaluates how prostate mass and testosterone affect voiding function in male and female mice, finding that testosterone, not prostate size, primarily drives sex differences in urinary function.

This study compares microbial diversity patterns in top- and subsoils of temperate grasslands along an aridity gradient, finding contrasting diversity trends and drivers between soil depths.

The paper shows that inhibiting phosphoinositide recycling in endothelial cells reduces tumor growth and angiogenesis by impairing VEGF signaling.

This study investigates how two HDAC inhibitors, sodium butyrate and Trichostatin A, induce distinct DNA methylation changes and affect X-chromosome inactivation in breast cancer cells.

This study determines the structure of colibactin using genetics, isotope labeling, tandem MS, and chemical synthesis, confirming its role in DNA cross-linking and colorectal cancer.

This study performs a proteomic analysis of Dnmt1 hypomorph colorectal cancer cells, revealing dysregulation of EMT and subcellular relocalization of Beta-Catenin.

This study shows that manganese toxicity in mice is reduced when exposure occurs via contaminated sediment rather than direct water exposure, suggesting metal-sediment interactions affect toxicity.

This study uses single-cell RNA sequencing to analyze cellular heterogeneity in mouse pancreatic ductal adenocarcinoma progression, identifying epithelial-to-mesenchymal transition, inflammatory macrophages, and fibroblast subtypes.

This study identifies IL-10-producing B cells in murine pericardial adipose tissues that promote cardiac recovery after acute myocardial infarction by resolving inflammation and reducing myocardial injury.

This study evaluates two norbormide-based fluorescent probes for in vivo imaging in Drosophila, finding they effectively label ER and mitochondria and are safe for long-term use.

This study optimizes fatty acid extraction from Coix seeds using chemometrics methods, finding that different extraction conditions are optimal for each seed type.

This paper identifies Spc105 as a new LaeA interaction partner in Aspergillus flavus, showing its role in development, secondary metabolism, and regulatory interdependence with LaeA.

The paper presents cryo-EM structures of InsP3R1 in activated and apo-states, revealing ligand-induced conformational changes that underlie channel gating.

This study identifies that CBL-mediated NCE regulates mitotic EGFR endocytosis, differing from interphase mechanisms.

This study compares the antioxidant activity of C3G and C3G liposomes in 2D and 3D cell cultures, finding greater effects in the 3D model.

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.

The paper identifies the SUMO-Ubiquitin-Cdc48 pathway as a negative regulator of RNA polymerase III in budding yeast, leading to proteasomal degradation of Pol III subunits and repression of transcription.