Z. Zhang

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This study shows dietary propionate causes intestinal oxidative stress in zebrafish by inhibiting SIRT3-mediated SOD2 depropionylation, leading to gut microbiota changes.

The paper develops new fluorogenic probes for live-cell and super-resolution microscopy with minimal label size and efficient quenching.

This study shows that changes in plasma cfDNA levels during chemotherapy predict clinical response in NSCLC patients, with specific insights for lung adenocarcinoma.

This study identifies POR and CYB5R1 as oxidoreductases that generate hydrogen peroxide, driving iron-dependent lipid peroxidation and ferroptosis.

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This study investigates how structural and dynamic features of the N-terminal domains of connexin 46 and 50 influence gap junction channel stability and conductance through molecular dynamics simulations and electrophysiology.

The paper investigates how direct energy transfer from photosystem II to photosystem I helps Scots pine survive winter by enabling sustained quenching and photoprotection.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

The paper creates a single nucleus multi-omics atlas of the murine pituitary, revealing cell type-specific regulatory mechanisms and identifying a cis-regulatory region linked to fertility.

This study introduces a new bioprinting method using a yield-stress granular gel to position and assemble tissue spheroids in 3D for cartilage and bone tissue construction.

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

This study identifies FSTL1-expressing adipocyte progenitors as drivers of age-related brown adipose tissue involution in rabbits and humans, with loss of FSTL1 causing iBAT atrophy in mice.

This study quantitatively synthesizes allelopathic effects across 385 studies, finding a 25% reduction in plant performance and variation influenced by method type, study duration, and phylogenetic distance.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study uses whole-genome sequencing of a PID cohort to identify genetic mutations and associations, revealing both monogenic and common variant contributions to immune dysfunction.

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

This paper introduces a fluorogenic DNA-PAINT probe that reduces background and increases imaging speed for 3D whole-cell DNA-PAINT.

This paper identifies PtrR as a dual activator/repressor in E. coli that regulates putrescine stress response and glutamate utilization through transcriptional control of multiple genes.

This study identifies two macrocyclic peptides that selectively modulate active and inactive states of Gs, offering a new approach for developing state-dependent GTPase inhibitors.

The paper uses multimodal single-cell profiling to identify a reduction in a polyfunctional Th17-like memory T cell state associated with tuberculosis progression.

The paper uses protein-proofed single-cell RNA profiling to identify tissue cells vulnerable to SARS-CoV-2 infection across 36 tissues, revealing lung and cardiac cells as top targets.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

The study tests Elton's diversity-invasibility hypothesis by showing that soils conditioned by more native species reduce biomass of alien plants.