Z. Zhang

This study shows that ANXA1sp reduces ischemic kidney injury by increasing SIRT3, which improves mitochondrial function and limits cell death.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

This paper develops a kinetic model of DnaA regulation in E. coli to explain how cell size and cell cycle are coordinated, reproducing experimental results and predicting responses to perturbations.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

The paper identifies STAT3 as an inhibitor of Myocardin-mediated cardiac hypertrophy by directly binding to Myocardin and suppressing its transcriptional activity.

This study investigates the role of the BMPR-II-SMAD3/MRTF complex in ASMC proliferation and migration in asthma, finding it contributes to airway remodelling.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study investigates how phosphorothioate substitutions affect RNA structure and dynamics using MD simulations, QM/MM calculations, and NMR experiments on a riboswitch model.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

The paper shows altruistic mutant cells in Streptomyces coelicolor experience mutational meltdown due to genomic deletions and increased mutation rates, leading to reduced fitness and sterility.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

This study identifies and characterizes 57 B3 superfamily genes in pineapple, revealing their chromosomal distribution, evolutionary relationships, and expression patterns during flower induction.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This paper describes a strategy to achieve brain-restricted mTOR inhibition using a combination of a brain-permeable inhibitor and a brain-impermeable ligand, while preserving systemic mTOR activity.

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This study shows DDX5 resolves a G-quadruplex in STAT1 mRNA 5UTR, enabling STAT1 translation and interferon signaling in HBV-infected hepatocytes.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

This study shows that combining free ammonia pretreatment with anaerobic digestion reduces antibiotic resistance gene abundances in sludge.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

The paper analyzes mutation spectra and compositional variability in SARS-CoV-2 clades to understand mutation patterns and their implications for viral proteomes.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

This study identifies TMEM39 as a conserved ER protein that facilitates collagen secretion and prevents ER stress by interacting with COPII components.