Richard L. Huganir

This study identifies the KIBRA-PKCγ signaling pathway as crucial for modulating memory performance in both mice and humans.

The paper develops tools to track synaptic plasticity in vivo by imaging endogenous AMPA receptors and generates a detailed spatiotemporal map of synaptic changes during behavior.

The paper shows that monocular deprivation in mouse visual cortex causes an all-or-none elimination of pyramidal cell connections to parvalbumin-positive interneurons, which is necessary for ocular dominance plasticity.

This study investigates the role of the Arc gene in hippocampal long-term potentiation and finds that Arc is not required for LTP maintenance, suggesting alternative mechanisms for memory storage.

This paper introduces TKIT, a CRISPR/Cas9 method for precise genomic knock-in in neurons, achieving up to 42% efficiency in mouse neurons and demonstrating its use in rat neurons for visualizing endogenous proteins.

This study shows that different SynGAP splice variants have distinct roles in synaptic plasticity and dendritic development through unique spatiotemporal expression and phase separation properties.

The paper investigates SynGAP splice variants' spatio-temporal expression and subcellular distribution in the developing mammalian brain, finding isoform-specific patterns and localization changes.

The paper identifies GluA2 upregulation in parvalbumin interneurons as a cause of gamma dysregulation in Syngap1+/- mice and shows that Perampanel rescues this dysfunction.

The paper identifies protein-protein interactions on Chr21 linked to intellectual disabilities, autism, and Alzheimer's by analyzing yeast two-hybrid screens and synaptic localization.

This study shows that neuronal EZH2 regulates neuronal morphogenesis and cognitive behavior in mice by controlling gene expression and dendritic spine density.