João A. Paulo

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

This study uses multi-omics analysis to show that chemical reprogramming reduces biological age in mouse fibroblasts by altering metabolism and mitochondrial function.

This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.

This study integrates multi-omics data from mouse embryonic stem cells to identify genetic drivers of proteome variability and uncover regulatory mechanisms in pluripotency.

This study uses patient-derived neurons to show that PGRN deficiency causes proteostasis breakdown and TDP-43 aggregation in FTD.

This study identifies genetic and molecular differences in RPE cells from geographic atrophy patients compared to controls using transcriptomic and proteomic analyses.

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.

The paper identifies genetic drivers of protein phosphorylation using multi-omics data from mouse tissues, revealing novel interactions and targets of PDK1 in obesity and diabetes.

The paper uses proximity labeling and mass spectrometry to identify proteins associated with internalized EGFR, revealing TFG's role in endosomal sorting.

The paper analyzes liver proteomes across three genetically diverse mouse populations to understand how genetic variation influences protein abundance and its relationship to phenotypes.

The paper creates two large-scale cell-line-specific human interactomes using affinity-purification mass spectrometry and identifies shared and cell-specific protein interactions.

This paper introduces a method to identify miRNA targets in vivo using Halo-Enhanced Ago2 Pulldown and demonstrates its application in mouse models.

This study shows that encapsulating hiPSCs in alginate improves their differentiation into pancreatic islet-like cells by reshaping the proteome and activating integrin signaling pathways.