biophysical modeling

This paper identifies how a human AGO-miRNA-trigger complex binds ZSWIM8 for CUL3-mediated polyubiquitylation, leading to target-directed miRNA degradation.

This study identifies ATG8 E3-like ligases as damage sensors that facilitate ESCRT recruitment to repair lysosomal membranes.

This study investigates how histidine residues in GM-CSF affect its structure, flexibility, and ligand binding at physiological pH.

This study compares the mechanical stability of antibody and nanobody interactions with SARS-CoV-2 variants using nanomechanical simulations.

This study identifies new acyclic monoterpene analogs with potent antiplasmodial activity and selectivity against P. falciparum in vitro, supported by favorable pharmacological properties.

The paper identifies the transsulfuration pathway as an oncogenic driver in pancreatic cancer metastasis through metabolomic analysis and functional validation.

This paper shows that effector proteins are mechanically labile, unfolding from the N-terminus, which facilitates their secretion via the Type III secretion system.

The paper develops an energy barrier model for membranes to analyze ion flow, current-voltage relations, and Donnan osmosis.

The paper identifies site-specific phosphorylation of Ser352 as the molecular switch driving Tau R4 aggregation under acidosis conditions.

This study identifies jasmonates and strigolactones as synergistic inducers of seed germination in root parasitic plants via KAI2d receptors.

This paper challenges the established model of actin import by showing IPO9 directly binds monomeric actin and competes with cofilin and profilin for actin binding.

This study identifies and characterizes the IsmB enzyme, which catalyzes a key step in coprostanol formation by the human gut microbiome, and links its presence to lower serum cholesterol levels.

The paper shows that biased ligands of the AT1R receptor stabilize different conformations that differentially modulate β-arrestin interactions, affecting signaling and desensitization.

This study identifies molecular changes in relapsed AML using transcriptomic analysis, highlighting pathways involved in chemoresistance and suggesting therapeutic targets.

The paper shows that amino acid restriction increases lung cancer cell sensitivity to ferroptosis by activating GCN2 and the integrated stress response, without affecting glutathione levels.

This study identifies a single amino acid difference in PGANT5 isoforms that affects substrate specificity and salivary gland function in Drosophila.

This paper investigates how the disordered C-terminal domain of TDP-43 interacts with RNA and identifies key residues and structural features that mediate RNA recognition and binding specificity.

This study defines REMORIN phylogeny based on C-terminal domains and predicts structural variations in membrane-binding interfaces that may influence their function and membrane organization.

The paper develops a Hodgkin-Huxley-type model of membrane potential bistability in MDA-MB-231 breast cancer cells, showing how ion channels and calcium dynamics drive voltage transients.

This paper develops a biophysical model to explain how MreB filaments localize to curved surfaces in bacteria, showing that their curvature preference is governed by mean and Gaussian curvatures.

This study identifies CRBN binders that induce or fail to induce CRBN closure, showing that closure is critical for degrader activity.

The paper identifies an EGFR/TBK1-dependent mitochondrial quality control mechanism that contributes to acquired resistance to temozolomide in glioma cells.

This study identifies montanine as a potent antiviral compound that inhibits RNA viruses by targeting translational elongation and GCN1-related stress responses.

This study identifies a sequence-encoded mechanism in plant proteins that enables thermoresponsive phase separation through low-complexity domains.

This study identifies PACER as a lncRNA that regulates lung adenocarcinoma progression through COX-2 signaling and structural dynamics.

This study identifies how HIV-1 Nef recruits Serinc3 by binding its N-terminal tail, revealing a conserved pocket important for antiviral resistance and drug target discovery.

This study shows stochasticity in protein distributions and interactions contributes to heterogeneity in mitochondrial MOMP during apoptosis, affecting both minority and majority MOMP scenarios.

The paper identifies CEND1 as a regulator of activity-dependent glucose metabolism by facilitating mitochondrial ATP channeling to hexokinase I.

This study identifies an ABC transporter in Anaerocellum bescii responsible for cello-oligosaccharide uptake, showing genetic deletion impairs growth on cellulose and cellobiose.

This paper introduces a reaction-diffusion model called LAGS to show that eukaryotic receptors can perform directional sensing through lateral diffusion, basal activity, and active degradation, without relying on downstream signaling pathways.