imaging

Temporal instability weakens entorhinal grid-like coding in older adults

This study shows that unstable hexadirectional signals in the entorhinal cortex of older adults correlate with poorer memory and reduced signal strength, suggesting grid-like coding instability rather than absence.

Perisynaptic matrix gene variants underlie DystoniaGeneNet endophenotypes in isolated focal dystonia

This paper uses a deep learning model to identify genetic variants associated with isolated focal dystonia by leveraging neuroimaging endophenotypes.

Cell Painting PLUS expands morphological profiling to enhance mechanistic understanding of compounds

The paper evaluates Cell Painting (CP) and Cell Painting PLUS (CPP) for predicting compound mechanisms of action, finding CPP better resolves off-target effects and improves MoA prediction for lysosome-related compounds.

Abnormal nuclear organization impairs adipogenic lineage commitment and terminal maturation in Hutchinson-Gilford progeria syndrome (HGPS)

This study shows that HGPS disrupts adipogenic lineage maturation through chromatin reorganization defects, despite normal lineage commitment rates.

geoGraph: Connectivity modelling across geographic space with hexagonal discrete global grids

geoGraph models organism movement and connectivity across geographic space using hexagonal grids, improving accuracy over rectangular grids by avoiding distortion.

Validating OpenCap Kinematics for ACL Injury-Related Movements In and Out of the Lab

This study evaluates OpenCap's accuracy in measuring ACL injury risk factors both in and out of the lab compared to optical motion capture.

Pufferfish inflation: drivers of axial and hoop skin strain and regional variation across the body

The paper measures skin strain and body volume changes in pufferfish during inflation, finding regional variations in strain and pressure dynamics.

B-REAL: A keypoint-less behavior platform for offline classification and real-time detection

B-REAL is a pose-free classifier that enables fast, accurate behavior detection in real-time with minimal training data and no pose estimation, improving closed-loop experiments.

MRI-Trackable Mesenchymal Stem Cells for Oncolytic Therapy: A Clinically Feasible Dual-Labeling Protocol

This study evaluates a dual-labeling protocol for mesenchymal stem cells with iron oxide particles and an oncolytic virus, showing preserved cellular function and MRI detectability.

Longitudinal diffusion tensor imaging identifies coordinated white matter remodeling during cocaine self-administration in mice

Heterochronic Uncoupling of Brain and Face Morphogenesis Drives Premature Fusion in Ciliary Transition Zone Mutants

The paper shows that reduced brain growth in ciliary transition zone mutants causes premature facial fusion by mechanically forcing facial prominences into convergence.

An implantable sensor network for large-scale cellular force mapping in living embryos

The paper introduces FORCENET, an implantable sensor network that maps intercellular forces in living embryos, revealing coordinated mechanical patterns regulated by developmental signaling.

Loss of LanC-like proteins impairs post-injury regeneration of aging muscles

This study shows that LanCL proteins are essential for muscle regeneration in aging mice, as their loss impairs regeneration and increases inflammation.

Label-free identification and classification of leukocyte subpopulations in peripheral blood smears by optical photothermal infrared spectroscopy

This paper uses optical photothermal infrared spectroscopy to classify leukocyte subpopulations in blood smears without staining, achieving accurate separation of granulocytes, lymphocytes, and monocytes.

β-Stability: Efficient, human-in-the-loop, graph-based curation of individual animal identities from images

The paper introduces β-Stability, a graph-based framework for semi-automated curation of animal identities from images, achieving high accuracy with limited expert review.

Symmetric Inheritance of the Cytoplasmic Bacterium Orientia tsutsugamushi During Mitosis

This study shows how two Rickettsiales bacteria, Orientia tsutsugamushi and Rickettsia rhipicephali, distribute during host cell division, with O. tsutsugamushi using microtubules for symmetric inheritance and R. rhipicephali inhibiting mitosis.

Amygdala Persistence in Aging: Replication and Extension of Puccetti et al. (2021)

This paper replicates and extends Puccetti et al. (2021) by examining age-related differences in affect and amygdala connectivity using fMRI and diary data.

Learned Audiovisual Predictability Modulates Depth-Resolved Hippocampal-Cortical Functional Coupling

The paper investigates how learned auditory predictability affects depth-resolved functional coupling between hippocampal subfields and cortical regions using 7T fMRI.

Spatial Patterns of White Matter Hyperintensities and Cognitive Function in Older Adults: A Community-Based Study

This study identifies spatial patterns of white matter hyperintensities (WMH) associated with cognitive decline in older adults using a community-based cohort.

Exposure to p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) Perturbs Cell State and Stem Cell Markers and Induces an Epidermal Phenotype in Human Breast Cells

This study shows that DDE exposure alters cell state and stem cell markers in breast cells, inducing an epidermal phenotype and upregulating keratinization pathways.

Deep learning-based counting and body-area measurement enable sensitive population-level endpoints in the Collembola reproduction test

This paper develops an automated system using deep learning to count and measure body area in springtails, providing sensitive population-level endpoints for ecotoxicological assessments.

Asymmetric listening conditions perturb verbal and nonverbal coordination dynamics during conversation

This study examines how asymmetric listening conditions affect verbal and nonverbal coordination in conversations, finding altered turn-taking and movement dynamics under noise.

A community benchmark enables high-resolution, cross-lab quantification of mouse social behavior

The paper introduces a benchmark dataset and tool for cross-lab quantification of mouse social behavior, achieving high-resolution and reproducible classification.

Optimising neural contrast and minimising tissue shrinkage in dragon lizard brains: buffered Lugol's iodine versus phosphotungstic acid for contrast-enhanced μCT

This study compares buffered Lugol's iodine and phosphotungstic acid for contrast-enhanced μCT of dragon lizard brains, finding buffered Lugol's iodine provides better contrast and less tissue shrinkage.

Reactions to Perceiving Tangible vs Virtual Impossible objects: Investigating Dimensions of Visual Reality

The paper investigates how perception reacts to tangible vs virtual impossible objects, finding that real objects create more surprise and perceptual impact than 2D representations.

ASD-FER: An Annotated Multi-Class Benchmark and Comparative Study for Facial Emotion Recognition in Children with Autism Spectrum Disorder

ASD-FER introduces a benchmark dataset for facial emotion recognition in children with ASD and evaluates multiple models, finding ViT achieves the highest accuracy on a held-out set.

Capturing Spatial Heterogeneity Using UAV-Derived Multispectral Phenotypes and Random Regression Models Improves Genetic Evaluation in Alfalfa Breeding Trials

Super-resolution imaging flow cytometry

This paper introduces super-resolution imaging flow cytometry (SR-IFC) to quantify organelle architecture heterogeneity at population scale, achieving sub-diffraction resolution in microbiology and immunology applications.

Losing the split ends: unraveling the mechanisms of fiber branching during blood clot formation

This study uses advanced microscopy to observe fibrin fiber branching during clot formation, revealing that branching occurs through mature fiber binding rather than splitting or protofibril association.

Can We Really See the World in Three Dimensions? An Exploratory Study with Finger Alignment Task and Ponzo Illusion

This study investigates depth perception limits using the Ponzo illusion and finger alignment task, finding reduced 3D perception beyond 8 degrees of retinal eccentricity.