Neurotransmitter Receptor Influence on Behavior

This study shows that estradiol, not DHT, is required for cocaine sensitization in male rats, highlighting its role in cocaine-induced neuroplasticity.

This study identifies neural signatures in the prelimbic prefrontal cortex associated with opioid-induced risk-taking behavior using a novel conflict task and neuronal recordings in rats.

This study investigates how dopamine signals in the ventral striatum relate to contingency during associative learning in mice, finding that TD learning models with ITI state representations explain the results better than contingency-based models.

This study investigates how serotonin deficiency affects aggression and social behaviors in mice using home cage monitoring and machine learning, revealing distinct behavioral patterns in Tph2-deficient mice.

This study examines how caloric states and amphetamine exposure affect dopamine neuron activity and their interconnections in zebrafish larvae.

This study examines how different feeding schedules modulate the locomotor and motor neuron responses to d-amphetamine in zebrafish larvae.

This study compares the effects of optogenetic activation or inhibition of direct and indirect striatal pathways in associative and sensorimotor striatum on action selection and locomotion.

This study examines how genetic variation in ULK4 affects brain activation in the reward system during a conditioned reward task, finding increased activation in specific brain regions for a particular variant.

This study shows that fluoxetine treatment during postnatal or juvenile periods leads to opposing effects on anxiety-depressive behaviors, gene expression, mitochondrial function, and neuronal structure in adult rats.

This study shows that KOR on VTA neurons, not NAcC neurons, prevents cocaine escalation by blocking the transition to SUD-like behavior.

The study finds that senescent male rats show reduced phasic dopamine signaling but still maintain dopamine-dependent Pavlovian conditioning.

The paper identifies the median raphe nucleus as a neural hub that flexibly controls behavioral strategies like exploitation, exploration, and disengagement through distinct neuronal populations.

This study shows that L-DOPA reduces alcohol and opioid self-administration in rats, suggesting a role for dopamine signaling in drug consumption across multiple substance classes.

The paper identifies distinct transcriptional profiles in striatal ensembles activated during initial vs. repeated cocaine exposure, revealing differences in neuronal recruitment and memory retrieval mechanisms.

This study identifies genetic loci associated with delay discounting in Heterogenous Stock rats using GWAS, implicating Slc35f1 and Adgrl3 as potential genes involved in this behavior.

This study shows that endogenous 17β-estradiol enhances reward prediction errors in the nucleus accumbens by reducing dopamine reuptake, thereby influencing reinforcement learning.

This paper demonstrates that (2R,6R)-hydroxynorketamine reverses maladaptive behaviors and prevents relapse in morphine-abstinent mice by enhancing BDNF and GluN2A signaling.

This study shows that dopamine signaling in the medial accumbens shell limits the duration of behaviors while reinforcing their frequency, mediated by D1 receptors.

The paper investigates neuromodulator dynamics in mice during a naturalistic reward-threat task, finding distinct roles for norepinephrine, dopamine, and serotonin in encoding motivational states.

This study investigates the roles of dopamine and acetylcholine in human decision-making, finding that dopamine affects both effort and delay discounting, while acetylcholine specifically influences effort discounting.

This study examines the effects of intermittent high fat and sugar diet exposure on food motivation and punishment resistance in rats, finding no persistent addiction-like behavior.

This study shows that burst firing of striatal cholinergic interneurons promotes extinction learning, while their pause is critical for reversing goal-directed behavior, and alcohol disrupts this process.

This study investigates how dopamine neurons in the mesolimbic system enable rapid revaluation of reward cues in changing environments using behavioral and neurophysiological methods in rats.

This study examines how morphine's effects on locomotor sensitization and context association differ between male and female mice, showing sex-dependent dose-related changes in behavior and memory.

The paper identifies transcriptomic differences in reward-specific ensembles in mice during cocaine and sucrose seeking using single-cell RNA sequencing.

The paper studies individual differences in reward-seeking behavior among isogenic mice in a social environment and links these differences to nicotine response and dopaminergic adaptability.

The paper shows that restoring arrestin-3 in dopamine-depleted striatum rescues behavioral sensitization by reactivating JNK3 and c-Jun phosphorylation.

This study shows that RGS6 in VTA dopamine neurons promotes EtOH seeking, reward, and relapse by enhancing DA transmission through GPCR-Gi/o-DAT signaling.

The paper identifies two distinct eLPBChAT projections to the amygdala and bed nucleus of the stria terminalis that mediate methamphetamine withdrawal anxiety and relapse.

This study shows that inhibiting the RMTg{lozenge}VTA pathway reduces cocaine seeking and has lasting effects on drug craving during abstinence.