Malaria Research and Control

This paper identifies UIS2 as a critical phosphatase for Plasmodium proliferation during the erythrocytic stage and reveals its structural mechanism for eIF2alpha dephosphorylation, suggesting it as a target for antimalarial drugs.

The paper introduces CUT&Tag and DiBioCUT&Tag methods to profile the epigenome of Plasmodium falciparum from low-input samples, improving upon ChIP-seq limitations.

This study designs an improved PvDBP-based immunogen using structure-guided methods to enhance its stability and antibody response against Plasmodium vivax.

The paper genotypes PIEZO1 STR alleles in malaria cases and controls, finding a modest protective effect of E756del against malaria.

The paper identifies PfTSEN1 as a tRNA splicing endonuclease in Plasmodium falciparum and demonstrates its inhibition by TSENi, a novel anti-malarial compound.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

The paper identifies EMAP3 as a new parasite protein exposed on the surface of P. berghei infected red blood cells, which interacts with EMAP1 but is not the main CD36-binding protein.

This study examines migration patterns among malaria vector species using genomic data, finding variation in genetic differentiation and migration rates across regions and species.

This study uses whole genome sequencing of Plasmodium vivax isolates to reveal a complex evolutionary history, showing that current Latin American populations mainly originated from an extinct European lineage with possible West African contributions.

This study evaluates the effectiveness of insecticide mixtures for resistance management using a mathematical model of polygenic resistance, finding that full-dose mixtures are most effective.

This study uses molecular dynamics simulations to analyze PfHT1 conformational changes and design specific inhibitors for malaria parasite glucose uptake.

This paper introduces dynamic mathematical models for polygenic insecticide resistance, showing full-dose mixtures remain the best strategy while sequences and rotations are similarly effective.

This study identifies a single mutation G454A in CYP9K1 as a driver of pyrethroid resistance in Anopheles funestus, reducing bed net efficacy and highlighting the need for resistance monitoring.

This study genotypes paired clinical isolates of Plasmodium vivax using molecular markers to differentiate between relapse and reinfection, identifying relapse episodes in some patients.

This study performs population genomic analysis of Plasmodium ovale species in sub-Saharan Africa, finding differences in nucleotide diversity and signatures of selection between the two species.

This study models the impact of gene drive releases on malaria transmission in West Africa, showing significant reductions in vector abundance and malaria prevalence when targeting multiple vector species.

The paper identifies glycolytic enzyme condensates in Plasmodium falciparum under low glucose conditions, showing they form distinct structures without lipid membranes.

This study shows that AlbuMAX supplemented media increases the production of transmission-competent Plasmodium falciparum gametocytes compared to serum.

This study identifies two mutations in CYP6P4a and CYP6P4b genes driving pyrethroid resistance in Anopheles funestus and develops DNA-based assays to detect these mutations in West Africa.

This study tests Anopheles larvae and adults using bioassays to assess susceptibility to chlorfenapyr, finding variability between species and populations.

The paper discovers knock-down resistance (kdr) mutations in Anopheles funestus, a major malaria vector, showing resistance to DDT but not deltamethrin.

This study identifies copy number variants (CNVs) as key drivers of insecticide resistance in Anopheles arabiensis, revealing new gene clusters and resistance mechanisms to deltamethrin and pirimiphos-methyl.

The paper introduces a new metric for insecticide resistance in mosquitoes and quantifies exposure variability in bioassays across Africa.

The paper identifies regional subpopulations and gene flow patterns of Plasmodium falciparum in Africa using genome-wide microsatellite loci from 992 isolates.

The paper investigates adaptive admixture at the Duffy locus in Oman, finding evidence of selection for Duffy null alleles linked to reduced P. vivax prevalence.

The paper confirms the presence of Anopheles stephensi in Yemen through molecular analysis of collected mosquito samples.

This study identifies the E205D mutation in CYP6P3 as a driver of pyrethroid resistance in Anopheles gambiae, showing its association with resistance and its interaction with kdr mutations.

This paper proposes a new ACT formulation (ferrous ACT) that combines traditional ACT with iron supplements to address artemisinin resistance in malaria.